Altered maternal metabolism during mild gestational hyperglycemia as a predictor of adverse perinatal outcomes: A comprehensive analysis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRudge, Marilza Vieira Cunha-
Autor(es): dc.creatorBarbosa, Angélica Mercia Pascon-
Autor(es): dc.creatorSobrevia, Luis-
Autor(es): dc.creatorGelaleti, Rafael Bottaro-
Autor(es): dc.creatorHallur, Raghavendra Lakshmana Shetty-
Autor(es): dc.creatorMarcondes, João Paulo Castro-
Autor(es): dc.creatorSalvadori, Daisy Maria Fávero-
Autor(es): dc.creatorPrudêncio, Caroline Baldini-
Autor(es): dc.creatorMagalhães, Claudia Garcia-
Autor(es): dc.creatorCosta, Roberto-
Autor(es): dc.creatorAbbade, Joelcio Francisco-
Autor(es): dc.creatorCorrente, José Eduardo-
Autor(es): dc.creatorCalderon, Iracema de Mattos Paranhos-
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Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionMild gestational hyperglycemia (MGH), as assessed using the normal oral glucose tolerance test (OGTT) and detection of an altered glycemic profile, is associated with adverse perinatal outcome. This study described the results of 40 years of research conducted at the Perinatal Diabetes Research Centre at São Paulo State University (UNESP), Brazil, on the maternal MGH environment and placental markers. This study also described the unidirectional relationship between MGH and excessive fetal growth, also supplying moderator analysis. In addition to hyperglycemia, MGH is associated with an increased incidence of hypertension, metabolic syndrome, persistent insulin resistance after pregnancy, and high risk of developing type 2 diabetes mellitus (T2DM) after pregnancy. Structural changes and functional abnormalities resulting from MGH were observed in placenta. The fully adjusted model concluded that the predictor variable (MGH), which creates a complex environment for the fetus, has a direct effect on excessive birth weight and produces a z-score for ratios of birth weight to gestational age of ≥2. Maternal age, pre-pregnancy BMI, number of previous pregnancies, numbers of prenatal visits, and 1 h OGTT are moderator variables that impact MGH and excessive fetal growth. These results show that maternal MGH has some characteristics associated with similar long-term T2DM development and similar adverse perinatal results to those of gestational diabetes mellitus (GDM) mothers, making it an intermediate maternal and placental marker between normoglycemic and GDM mothers.-
Idioma: dc.languageen-
Relação: dc.relationBiochimica et Biophysica Acta - Molecular Basis of Disease-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectApoptosis-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectGene expression-
Palavras-chave: dc.subjectGestational diabetes mellitus-
Palavras-chave: dc.subjectInflammatory mediators-
Palavras-chave: dc.subjectInsulin resistance-
Palavras-chave: dc.subjectIRS-1 gene-
Palavras-chave: dc.subjectLarge for gestational age-
Palavras-chave: dc.subjectMild gestational hyperglycemia-
Palavras-chave: dc.subjectModerator analysis-
Palavras-chave: dc.subjectNatural killer cells-
Palavras-chave: dc.subjectPlacenta-
Título: dc.titleAltered maternal metabolism during mild gestational hyperglycemia as a predictor of adverse perinatal outcomes: A comprehensive analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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