Can non-collagenous proteins be employed for the differential diagnosis among fibrous dysplasia, cemento-osseous dysplasia and cemento-ossifying fibroma?

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorVeltrini, Vanessa Cristina-
Autor(es): dc.creatorFigueira, Jéssica Araújo-
Autor(es): dc.creatorSantin, Gabriela Cristina-
Autor(es): dc.creatorde Sousa, Suzana Cantanhede Orsini Machado-
Autor(es): dc.creatorde Araújo, Ney Soares-
Data de aceite: dc.date.accessioned2021-03-11T01:37:48Z-
Data de disponibilização: dc.date.available2021-03-11T01:37:48Z-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.prp.2019.152450-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/189118-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/189118-
Descrição: dc.descriptionDifferential diagnosis among fibrous dysplasias, cemento-ossifying fibromas and cemento-osseous dysplasias is difficult, since there is considerable overlap of histologic features, but also extremely important, since they differ greatly in etiology, clinical behaviour, prognosis and terapeuthic approach. There is no data about the use of immunohistochemistry, a viable and accessible technique, for this purpose. The objective of this study was to investigate, comparatively, the immunohistochemical expression of major non-collagenous proteins (osteonectin [ON], osteopontin [OP], bone sialoprotein [BSP] and osteocalcin [OC]) of mineralized tissue extracellular matrix in 22 cases of fibrous dysplasias, 16 of cemento-ossifying fibromas and 16 of cemento-osseous dysplasias. ON maintained the same expression profile in all cases; the staining for OP was negative in fusiform cells producing cementoid globules and weak, as well as heterogeneous, in high mineralized matrixes; there was negativity for BSP in cementoid globules and in the fusiform cells that produce them, differently from the strong positive expression found in the majority of bone trabeculae and their peripheral cuboidal osteoblasts; and finally, the immuno-reactivity for OC was weak, except in cuboidal osteoblasts and osteocytes. We can conclude that the nature of mineralized structure and the cellular phenotype are much more responsible for variability in immunohistochemical profile than the type of lesion (fibrous dysplasias, cemento-ossifying fibromas and cemento-osseous dysplasias) which makes difficult, at least for a while, the use of these proteins with diagnosis purpose.-
Idioma: dc.languageen-
Relação: dc.relationPathology Research and Practice-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectBenign mesenchymal odontogenic tumours-
Palavras-chave: dc.subjectBone sialoprotein-
Palavras-chave: dc.subjectFibro-osseous lesions-
Palavras-chave: dc.subjectOsteocalcin-
Palavras-chave: dc.subjectOsteonectin-
Palavras-chave: dc.subjectOsteopontin-
Título: dc.titleCan non-collagenous proteins be employed for the differential diagnosis among fibrous dysplasia, cemento-osseous dysplasia and cemento-ossifying fibroma?-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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