Warmblood Fragile Foal Syndrome causative single nucleotide polymorphism frequency in Warmblood horses in Brazil

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDias, Natalia Moraes-
Autor(es): dc.creatorde Andrade, Danilo Giorgi Abranches-
Autor(es): dc.creatorTeixeira-Neto, Antônio Raphael-
Autor(es): dc.creatorTrinque, Camila Moreira-
Autor(es): dc.creatorOliveira-Filho, José Paes de-
Autor(es): dc.creatorWinand, Nena J.-
Autor(es): dc.creatorAraújo, João Pessoa-
Autor(es): dc.creatorBorges, Alexandre Secorun-
Data de aceite: dc.date.accessioned2021-03-11T01:37:42Z-
Data de disponibilização: dc.date.available2021-03-11T01:37:42Z-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.tvjl.2019.05.002-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/189082-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/189082-
Descrição: dc.descriptionWarmblood Fragile Foal Syndrome (WFFS)is an autosomal recessive genetic disorder caused by a mutation in the procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (PLOD1)gene, associated with collagen biosynthesis. WFFS causes lesions and malformations of the skin in neonatal foals, and abortion. The objective of this study was to investigate the allelic frequency of the single nucleotide polymorphism (SNP)c.2032G>A in the PLOD1 gene in warmblood samples from Brazil. Of the 374 Warmblood horses tested, 41 animals (11%)were identified as heterozygous for the WFFS SNP and 333 (89%)were homozygous for the wild-type allele (N/N), and therefore, the allele frequency was 5.5%. This study highlights the importance of control measures to prevent an increase in the incidence of WFFS in Warmblood horses worldwide.-
Formato: dc.format101-102-
Idioma: dc.languageen-
Relação: dc.relationVeterinary Journal-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectCollagen-
Palavras-chave: dc.subjectConnective tissue-
Palavras-chave: dc.subjectMutation-
Palavras-chave: dc.subjectPLOD1gene-
Título: dc.titleWarmblood Fragile Foal Syndrome causative single nucleotide polymorphism frequency in Warmblood horses in Brazil-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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