Paracrine/autocrine control of spermatogenesis by gonadotropin-inhibitory hormone

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorFallah, Hamideh P.-
Autor(es): dc.creatorTovo-Neto, Aldo-
Autor(es): dc.creatorYeung, Edward C.-
Autor(es): dc.creatorNóbrega, Rafael H.-
Autor(es): dc.creatorHabibi, Hamid R.-
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Descrição: dc.descriptionNatural Sciences and Engineering Research Council of Canada-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionNatural Sciences and Engineering Research Council of Canada: 1021837-
Descrição: dc.descriptionProcesso FAPESP: 2014/07620-7-
Descrição: dc.descriptionProcesso FAPESP: 2014/16280-5-
Descrição: dc.descriptionProcesso FAPESP: 2017/09218-0-
Descrição: dc.descriptionControl of testicular development is multifactorial and involves a number of hypothalamic, hypophyseal and peripheral hormones. Here, we investigated direct action of zebrafish gonadotropin-inhibitory hormone (zGnih) which is expressed in the testis, on spermatogenesis in zebrafish, in vitro. Treatment with zGnih at the lower doses (10 and 100 nM) inhibited gonadotropin-induced spermatids/spermatozoa (SPD/SPZ) production. However, at the highest dose (1000 nM), zGnih increased basal number of SPD/SPZ and showed paradoxical effect. The effects of zGnih on testosterone and SPD/SPZ production was blocked in the presence of androgen receptor antagonist, flutamide (FLU). A number of transcripts were also measured to better understand zGnih mechanisms of action on zebrafish spermatogenesis. Our results provide strong support for the hypothesis that locally produced zGnih is a component of the complex multifactorial system that regulates testicular development and function in adult zebrafish, in part, by changes in testicular steroidogenesis and regulation of gonadotropin-induced response.-
Idioma: dc.languageen-
Relação: dc.relationMolecular and Cellular Endocrinology-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectFlutamide (FLU)-
Palavras-chave: dc.subjectGonadotropin-inhibitory hormone (Gnih)-
Palavras-chave: dc.subjectHuman chorionic gonadotropin (hCG)-
Palavras-chave: dc.subjectSpermatids (SPD)-
Palavras-chave: dc.subjectSpermatozoa (SPZ)-
Palavras-chave: dc.subjectTestosterone-
Palavras-chave: dc.subjectZebrafish gnih (zGnih)-
Título: dc.titleParacrine/autocrine control of spermatogenesis by gonadotropin-inhibitory hormone-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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