Waiting DAAs list mortality impact in HCV cirrhotic patients

Registro completo de metadados
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSilva, Giovanni Faria-
Autor(es): dc.creatorde ANDRADE, Vanessa Gutierrez-
Autor(es): dc.creatorMoreira, Alecsandro-
Data de aceite: dc.date.accessioned2021-03-11T01:36:44Z-
Data de disponibilização: dc.date.available2021-03-11T01:36:44Z-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2018-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/s0004-2803.201800000-76-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/188755-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/188755-
Descrição: dc.descriptionBackground – The infection for the hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality through its evolution to liver cirrhosis, end-stage liver complications and hepatocellular carcinoma. Currently, the new drugs for the HCV infection, based on direct antiviral agents, have changed the outcomes in this setting. Objective – To assess death incidence, during the wait for the treatment with the new drugs, and to analyze which independent variable (age, sex, ascite, HDA, albumin, α-fetoprotein, platelets and Meld score) had relation with death. Methods – Prospective study with cirrhotic patients by HCV. Inclusion: cirrhotic patients by hepatic biopsy (METAVIR), clinic or image, detectable RNA (HCV). Exclusion: Other stages of hepatic fibrosis and hepatocellular carcinoma. Descriptive statistic in continue variables. Fisher Exact and Kaplan Meier and Cox Regression Analysis to assess the association of variables studied with death. P<0.05. Results – A total of 129 patients were included. Of this, 73% were men. Mean age was 57.8±12.1, albumin of 3.5±0.6 mg/dL, platelets of 123.4±59.6 and Meld score of 10.59±3.56. The time of observation was 11.2±3.26 months, and the number of death 9/129 (6,9%). The Kaplan-Meier showed association between death with albumin lower than 2.9 (0.0006), MELD score higher than 15 (0.007) and α-fetoprotein higher than 40 ng/mL (<0.0001). Adjusted Cox Regression Analysis showed that α-fetoprotein higher than 40 ng/ml could be considered an independent risk for death. Conclusion – We conclude that, patients with advanced cirrhosis should be prioritized for treatment with direct antiviral agents.-
Formato: dc.format343-345-
Idioma: dc.languageen-
Relação: dc.relationArquivos de Gastroenterologia-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectDrug therapy. Liver cirrhosis-
Palavras-chave: dc.subjectHepacivirus. Liver cirrhosis-
Palavras-chave: dc.subjectMortality-
Título: dc.titleWaiting DAAs list mortality impact in HCV cirrhotic patients-
Título: dc.titleImpacto da lista de espera para aads em pacientes cirróticos por VHC-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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