Structure elucidation of a bioactive fucomannogalactan from the edible mushroom Hypsizygus marmoreus

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorOliveira, Ruberney S.-
Autor(es): dc.creatorBiscaia, Stellee M. P.-
Autor(es): dc.creatorBellan, Daniel L.-
Autor(es): dc.creatorViana, Sthefany R. F.-
Autor(es): dc.creatorDi-Medeiros Leal, Maria Carolina-
Autor(es): dc.creatorVasconcelos, Ana Flora D.-
Autor(es): dc.creatorLiao, Luciano M.-
Autor(es): dc.creatorTrindade, Edvaldo S.-
Autor(es): dc.creatorCarbonero, Elaine R.-
Data de aceite: dc.date.accessioned2021-03-11T01:17:48Z-
Data de disponibilização: dc.date.available2021-03-11T01:17:48Z-
Data de envio: dc.date.issued2019-10-04-
Data de envio: dc.date.issued2019-10-04-
Data de envio: dc.date.issued2019-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.carbpol.2019.115203-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/186171-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/186171-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionA fucomannogalactan (FMG-Hm), with a molecular weight of 17.1 kDa, obtained from fruiting bodies of Hypsizygus marmoreus exhibited promising in vitro antimelanoma effects. FMG-Hm was not cytotoxic, nor did it alter the cell morphology and proliferation, but was able to inhibit colony-forming ability and cell migration in B16-F10 murine melanoma cells. An analysis of the monosaccharide composition indicated that FMG-Hm was composed of fucose, mannose, and galactose in a ratio of 1.00:1.08:3.17. The FMG-Hm was structurally characterized based on methylation analysis, partial acid hydrolysis, and NMR experiments. The results indicated that FMG-Hm contained a alpha-(1 -> 6)-linked galactopyranosyl main chain, partially substituted at O-2 by non-reducing ends of alpha-L-fucopyranose and beta-D-mannopyranose. The predicted structure of the heteropolysaccharide was established as: [GRAPHICS] .-
Formato: dc.format9-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationCarbohydrate Polymers-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectHypsizygus marmoreus-
Palavras-chave: dc.subjectMushroom-
Palavras-chave: dc.subjectFucomannogalactan-
Palavras-chave: dc.subjectChemical structure-
Palavras-chave: dc.subjectAntimelanoma-
Palavras-chave: dc.subjectB16-F10 cell-
Título: dc.titleStructure elucidation of a bioactive fucomannogalactan from the edible mushroom Hypsizygus marmoreus-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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