Trans, trans-farnesol, an antimicrobial natural compound, improves glass ionomer cement properties

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorFreire de Castilho, Aline Rogeria-
Autor(es): dc.creatorRosalen, Pedro Luiz-
Autor(es): dc.creatorSouza Araujo, Isaac Jordao de-
Autor(es): dc.creatorKitagawa, Igor Lebedenco-
Autor(es): dc.creatorGoncalves de Araujo Costa, Cecilia Atem-
Autor(es): dc.creatorJanal, Malvin N.-
Autor(es): dc.creatorAlves, Marcelo Correa-
Autor(es): dc.creatorDuarte, Simone-
Autor(es): dc.creatorLisboa Filho, Paulo Noronha-
Autor(es): dc.creatorStipp, Rafael Nobrega-
Autor(es): dc.creatorPuppin-Rontani, Regina Maria-
Data de aceite: dc.date.accessioned2021-03-11T01:17:47Z-
Data de disponibilização: dc.date.available2021-03-11T01:17:47Z-
Data de envio: dc.date.issued2019-10-04-
Data de envio: dc.date.issued2019-10-04-
Data de envio: dc.date.issued2019-08-20-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0220718-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/186167-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/186167-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionProcesso FAPESP: 2014/01723-9-
Descrição: dc.descriptionProcesso FAPESP: 2015/08871-6-
Descrição: dc.descriptionCNPq: 443036/2014-4-
Descrição: dc.descriptionCNPq: 310522/2015-3-
Descrição: dc.descriptionCNPq: 312868/2017-0-
Descrição: dc.descriptionA series of experiments were conducted to characterize a novel restorative material. We explored the effect on biological, physical and chemical properties of glass ionomer cement (GIC) adding-the naturally occurring tt-farnesol (900 mM). Two groups were accomplished for all assays: GIC+tt-farnesol and GIC (control). Biological assays: 1) agar diffusion against some cariogenic bacteria; 2) S. mutans biofilm formation and confocal laser scanning microscopy-CLSM. 3) gtfB, gtfC, gtfD, gbpB, vicR, and covR expression; 4) MTT and microscopic morphology. Physical properties assays: 1) roughness; 2) hardness; 3) compressive strength and 4) diametral tensile strength. Chemical assay: Raman spectroscopy. The adding of tt-farnesol to GIC led to larger zones of inhibition (p<0.05), biofilms with a short-term reduction in bacterial viability but similar biomass (p>0.05). Polysaccharides levels increased over time, similarly over groups (p>0.05). Viable and non-viable S. mutans were seen on the specimens' surface by CLSM but their virulence was not modulated by tt-farnesol. The tt-farnesol increased the HaCaT cell viability without impact on compressive and diametral tensile strength and roughness although the hardness was positively affected (p<0.05). Raman confirmed the presence of tt-farnesol. The incorporation of tt-farnesol into GIC inhibited the growth of cariogenic bacteria but had a little effect on the composition, structure and physiology of the biofilm matrices. Also, the tt-farnesol increased the hardness and the biocompatibility of the GIC, not influencing negatively other physical properties of the restorative material.-
Formato: dc.format16-
Idioma: dc.languageen-
Publicador: dc.publisherPublic Library Science-
Relação: dc.relationPlos One-
Direitos: dc.rightsopenAccess-
Título: dc.titleTrans, trans-farnesol, an antimicrobial natural compound, improves glass ionomer cement properties-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.