Chronic alcohol consumption changes blood marker profile and bone density in rats with apical periodontitis

Registro completo de metadados
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDal-Fabbro, Renan-
Autor(es): dc.creatorAlmeida, Melyna Marques de-
Autor(es): dc.creatorCosme-Silva, Leopoldo-
Autor(es): dc.creatorNeto, Antonio H. C.-
Autor(es): dc.creatorSalzedas, Leda M. P.-
Autor(es): dc.creatorCintra, Luciano T. A.-
Autor(es): dc.creatorFilho, Joao E. G.-
Data de aceite:
Data de disponibilização:
Data de envio:
Data de envio:
Data de envio:
Fonte completa do material: dc.identifier
Fonte completa do material: dc.identifier
Fonte: dc.identifier.uri
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionAim The aim of the present study was to evaluate apical periodontitis (AP) development in rats under a chronic alcohol diet by calcium, phosphorus, and alkaline phosphatase blood levels in addition to histological and radiographic analyses. Methods Thirty-two rats were arranged into four groups: (a) group 1: without apical periodontitis and on a regular diet; (b) group 2: AP and on a regular diet; (c) group 3: alcoholic diet without apical periodontitis; and (d) group 4: alcoholic diet and apical periodontitis. Alcoholic solution at 20% was given throughout the 8-week experiment. AP was induced in the first molars at the end of the 7th week. At the end, the animals were anesthetized for blood collection, followed by euthanasia, and jaws were removed for digital radiography and histological processing. The level of significance was 5%. Results Calcium levels remained constant in all groups (P > 0.05). Group 4 showed a higher phosphorous level than group 2 (P < 0.05). The alkaline phosphatase activity was higher in group 3 compared with group 1 (P < 0.05). Three animals in group 4 exhibited a severe inflammatory reaction, whereas the animals in group 2 did not demonstrate any reaction (P < 0.05). The lowest value of radiographic density was given by group 4 (P < 0.05). Conclusions Chronic alcohol consumption increased serum phosphorus and decreased bone density in the periapical region, favoring AP development.-
Formato: dc.format6-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-Blackwell-
Relação: dc.relationJournal Of Investigative And Clinical Dentistry-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectalcohol consumption-
Palavras-chave: dc.subjectalcoholism-
Palavras-chave: dc.subjectapical periodontitis-
Palavras-chave: dc.subjectbone resorption-
Palavras-chave: dc.subjectendodontic-
Título: dc.titleChronic alcohol consumption changes blood marker profile and bone density in rats with apical periodontitis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.