Antimicrobial activity of nitrochalcone and pentyl caffeate against hospital pathogens results in decreased microbial adhesion and biofilm formation

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorAlmeida Sayao de Emeri, Fernanda Teresinha de-
Autor(es): dc.creatorRosalen, Pedro Luiz-
Autor(es): dc.creatorPaganini, Eder Ramos-
Autor(es): dc.creatorRocha Garcia, Mayara Aparecida-
Autor(es): dc.creatorNazare, Ana Carolina-
Autor(es): dc.creatorLazarini, Josy Goldoni-
Autor(es): dc.creatorAlencar, Severino Matias de-
Autor(es): dc.creatorRegasini, Luis Octavio-
Autor(es): dc.creatorOrlandi Sardi, Janaina de Cassia-
Data de aceite: dc.date.accessioned2021-03-11T01:16:07Z-
Data de disponibilização: dc.date.available2021-03-11T01:16:07Z-
Data de envio: dc.date.issued2019-10-04-
Data de envio: dc.date.issued2019-10-04-
Data de envio: dc.date.issued2019-04-03-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/08927014.2019.1574763-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/185622-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/185622-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionCNPq: 74335/2013-5-
Descrição: dc.descriptionCNPq: 132790/2018-1-
Descrição: dc.descriptionCAPES: 0.01-
Descrição: dc.descriptionThe present study investigated the antimicrobial, anti-adhesion and anti-biofilm activity of the modified synthetic molecules nitrochalcone (NC-E05) and pentyl caffeate (C5) against microorganisms which have a high incidence in hospital-acquired infections. The compounds were further tested for their preliminary systemic toxicity in vivo. NC-E05 and C5 showed antimicrobial activity, with minimum inhibitory concentrations (MICs) ranging between 15.62 and 31.25g ml(-1). Treatment with NC-E05 and C5 at 1xMIC and/or 10xMIC significantly reduced mono or mixed-species biofilm formation and viability. At MIC/2, the compounds decreased microbial adhesion to HaCaT keratinocytes from 1 to 3h (p<0.0001). In addition, NC-E05 and C5 demonstrated low toxicity in vivo in the Galleria mellonella model at anti-biofilm concentrations. Thus, the chemical modification of these molecules proved to be effective in the proposed anti-biofilm activity, opening opportunities for the development of new antimicrobials.-
Formato: dc.format129-142-
Idioma: dc.languageen-
Publicador: dc.publisherTaylor & Francis Ltd-
Relação: dc.relationBiofouling-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectMixed biofilm-
Palavras-chave: dc.subjectnitrochalcone-
Palavras-chave: dc.subjectpentyl caffeate-
Palavras-chave: dc.subjectStaphylococcus aureus-
Palavras-chave: dc.subjectCandida albicans-
Título: dc.titleAntimicrobial activity of nitrochalcone and pentyl caffeate against hospital pathogens results in decreased microbial adhesion and biofilm formation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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