Kinetics of venom and antivenom serum levels, clinical evaluation and therapeutic effectiveness in dogs inoculated with Crotalus durissus terrificus venom

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSangiorgio, F.-
Autor(es): dc.creatorSakate, M.-
Autor(es): dc.creatorNogueira, R. M. B.-
Autor(es): dc.creatorAraújo Junior, J. P.-
Autor(es): dc.creatorChavez-Olortegui, C.-
Data de aceite: dc.date.accessioned2021-03-10T17:11:33Z-
Data de disponibilização: dc.date.available2021-03-10T17:11:33Z-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2008-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S1678-91992008000100008-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/18279-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/18279-
Descrição: dc.descriptionThis work evaluated the clinical and therapeutic aspects as well as serum levels of venom and antivenom IgG by enzyme-linked immunosorbent assay (ELISA) in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into four groups of seven animals each, Group I: only venom; Group II, venom + 50 ml of anti-bothropic-crotalic serum (50mg) + fluid therapy; Group III, venom + 50 ml of anti-bothropic-crotalic serum + fluid therapy + urine alkalination; Group IV, 50 ml of anti-bothropic-crotalic serum. The lyophilized venom of Crotalus durissus terrificus was reconstituted in saline solution and subcutaneously inoculated at the dose of 1mg/kg body weight. The dogs presented clinical signs of local pain, weakness, mandibular ptosis, mydriasis, emesis and salivation. The venom levels detected by ELISA ranged from 0 to 90ng/ml, according to the severity of the clinical signs. Serum antivenom ranged from 0 to 3ug/ml and was detected for up to 138h after treatment. ELISA results showed the effectiveness of the serum therapy for the venom neutralization.-
Formato: dc.format100-112-
Idioma: dc.languageen-
Publicador: dc.publisherUniversidade Estadual Paulista (UNESP), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)-
Relação: dc.relationJournal of Venomous Animals and Toxins Including Tropical Diseases-
Relação: dc.relation1.782-
Relação: dc.relation0,573-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectCrotalus durissus terrificus-
Palavras-chave: dc.subjectdogs-
Palavras-chave: dc.subjectclinical signs-
Palavras-chave: dc.subjectELISA-
Título: dc.titleKinetics of venom and antivenom serum levels, clinical evaluation and therapeutic effectiveness in dogs inoculated with Crotalus durissus terrificus venom-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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