Th1/Th2 cytokine production by clove-treated mice

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBachiega, Tatiana Fernanda-
Autor(es): dc.creatorOrsatti, Claudio Lera-
Autor(es): dc.creatorPagliarone, Ana Carolina-
Autor(es): dc.creatorMissima, Fabiane-
Autor(es): dc.creatorBarreto Sousa, Joao Paulo-
Autor(es): dc.creatorBastos, Jairo Kenupp-
Autor(es): dc.creatorSforcin, Jose Mauricio-
Data de aceite: dc.date.accessioned2021-03-10T17:11:26Z-
Data de disponibilização: dc.date.available2021-03-10T17:11:26Z-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2009-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/14786410902809328-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/18236-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/18236-
Descrição: dc.descriptionAlthough clove possesses several biological and therapeutic properties, its immunomodulatory action has not been fully investigated. The goal of this work was to investigate the effect of administration of the water extract of clove over a short-term to BALB/c mice on Th1 (IFN-gamma and IL-2) and Th2 (IL-4 and IL-10) cytokine production. After treatment, spleen cells were aseptically removed and cells were stimulated with concanavalin A. Supernatants of cell cultures were used for cytokine determination by ELISA. The chemical composition of the extract was also carried out, revealing that eugenol(4-allyl-2-methoxyphenol) was the major component in our sample. Although the anti-inflammatory action of clove has been mentioned, our data showed that clove administration to mice did not influence the Th1/Th2 cytokine balance. Further studies dealing with cytokine expression and production will provide a better understanding of clove's immunomodulatory and anti-inflammatory actions, using different extract concentrations and different intake periods.-
Formato: dc.format1552-1558-
Idioma: dc.languageen-
Publicador: dc.publisherTaylor & Francis Ltd-
Relação: dc.relationNatural Product Research-
Relação: dc.relation1.928-
Relação: dc.relation0,671-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectclove-
Palavras-chave: dc.subjectcytokines-
Palavras-chave: dc.subjectspleen cells-
Palavras-chave: dc.subjectimmunomodulation-
Título: dc.titleTh1/Th2 cytokine production by clove-treated mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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