Developmental programming of the female neuroendocrine system by steroids

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorAbruzzese, Giselle Adriana-
Autor(es): dc.creatorCrisosto, Nicolás-
Autor(es): dc.creatorDe Grava Kempinas, Wilma-
Autor(es): dc.creatorSotomayor-Zárate, Ramón-
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Descrição: dc.descriptionDevelopmental programming refers to processes that occur during early life that may have long-term consequences, modulating adult health and disease. Complex diseases, such as diabetes, cancer and cardiovascular disease, have a high prevalence in different populations, are multifactorial, and may have a strong environmental component. The environment interacts with organisms, affecting their behaviour, morphology and physiology. This interaction may induce permanent or long-term changes, and organisms may be more susceptible to environmental factors during certain developmental stages, such as the prenatal and early postnatal periods. Several factors have been identified as responsible for inducing the reprogramming of various reproductive and nonreproductive tissues. Among them, both natural and synthetic steroids, such as endocrine disruptors, are known to have either detrimental or positive effects on organisms depending on the dose of exposure, stage of development and biological sexual background. The present review focuses on the action of steroids and endocrine disruptors as agents involved in developmental programming and on their modulation and effects on female neuroendocrine functions.-
Idioma: dc.languageen-
Relação: dc.relationJournal of Neuroendocrinology-
Relação: dc.relation1,554-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectdevelopmental programming-
Palavras-chave: dc.subjectendocrine disruptors-
Palavras-chave: dc.subjectglucocorticoids-
Palavras-chave: dc.subjectgonadal steroids-
Título: dc.titleDevelopmental programming of the female neuroendocrine system by steroids-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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