Biodentine and MTA modulate immunoinflammatory response favoring bone formation in sealing of furcation perforations in rat molars

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorda Fonseca, Tiago Silva-
Autor(es): dc.creatorSilva, Guilherme F.-
Autor(es): dc.creatorGuerreiro-Tanomaru, Juliane M.-
Autor(es): dc.creatorDelfino, Mateus Machado-
Autor(es): dc.creatorSasso-Cerri, Estela-
Autor(es): dc.creatorTanomaru-Filho, Mário-
Autor(es): dc.creatorCerri, Paulo Sérgio-
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Descrição: dc.descriptionObjectives: Evaluate the tissue reaction of periodontium subjacent to furcation perforations in rat molars sealed with Biodentine or mineral trioxide aggregate (MTA). Materials and methods: The pulp chamber floor of right upper first molars of 60 rats was perforated and filled with Biodentine, MTA, or cotton pellet (sham); the left first molars were used as control. After 7, 15, 30, and 60 days, maxillary fragments were processed for paraffin-embedding. The periodontal space (PS), volume density of inflammatory cells (VvIC) and fibroblasts (VvFb), number of osteoclasts, and collagen content were obtained. Interleukin-6 (IL-6) and osterix (osteoblast marker) were detected by immunohistochemistry. The data were submitted to ANOVA and Tukey’s test (p ≤ 0.05). Results: At 7 days, high values in VvIC, IL-6-immunolabeled cells, and osteoclasts were accompanied by reduced collagen content in enlarged PS of experimental groups. At all periods, VvIC, number of osteoclasts and IL-6, and PS were higher in sham than in Biodentine and MTA (p < 0.0001). From 7 to 60 days, significant reduction in VvIC, IL-6 immunoexpression, and osteoclasts was accompanied by significant increase in VvFb, osteoblasts, and collagen in Biodentine and MTA groups. At 60 days, significant differences in VvIC, PS, IL-6, osteoclasts, and osteoblasts were not found between Biodentine and MTA. Significant differences in the osteoclast number were not observed among Biodentine, MTA, and control groups while osteoblasts number was higher in Biodentine and MTA groups. Conclusions: Despite the initial inflammatory reaction and bone resorption, the sealing of furcation perforations with Biodentine and MTA favors the repair of periodontal tissues. Clinical relevance: Biodentine and MTA exhibit potential as repair material in the treatment of furcation perforations.-
Formato: dc.format1-16-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
Relação: dc.relation0,986-
Relação: dc.relation0,986-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectBone remodeling-
Palavras-chave: dc.subjectCalcium silicate cement-
Palavras-chave: dc.subjectImmunohistochemistry-
Palavras-chave: dc.subjectPeriodontium repair-
Título: dc.titleBiodentine and MTA modulate immunoinflammatory response favoring bone formation in sealing of furcation perforations in rat molars-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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