Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity

Registro completo de metadados
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSingulani, Junya de Lacorte-
Autor(es): dc.creatorScorzoni, Liliana-
Autor(es): dc.creatorLourencetti, Natália Manuela Strohmayer-
Autor(es): dc.creatorOliveira, Luana Rossi-
Autor(es): dc.creatorConçolaro, Rosana Silva-
Autor(es): dc.creatorda Silva, Patricia Bento-
Autor(es): dc.creatorNazaré, Ana Carolina-
Autor(es): dc.creatorPolaquini, Carlos Roberto-
Autor(es): dc.creatorVictorelli, Francesca Damiani-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorRegasini, Luis Octávio-
Autor(es): dc.creatorFusco Almeida, Ana Marisa-
Autor(es): dc.creatorMendes Giannini, Maria José Soares-
Data de aceite: dc.date.accessioned2021-03-11T00:57:33Z-
Data de disponibilização: dc.date.available2021-03-11T00:57:33Z-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2018-08-25-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijpharm.2018.06.013-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/179967-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/179967-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionProcesso FAPESP: 2013/10917-9-
Descrição: dc.descriptionProcesso FAPESP: 2014/10446-9-
Descrição: dc.descriptionProcesso FAPESP: 2015/03700-9-
Descrição: dc.descriptionParacoccidioidomycosis (PCM) is a systemic mycosis endemic in Latin America, caused by Paracoccidioides spp. A limited number of antifungal agents are available and the search for new compounds has increased. Additionally, nanostructured lipid system (NLS) has emmerged as an interesting strategy to carrier compounds for the treatment of mycosis. In this work, the antifungal efficacy and toxicity of dodecyl gallate (DOD) associated with a NLS was evaluated through in vitro and in vivo tests. DOD showed good in vitro antifungal activity and low toxicity in lung fibroblasts and zebrafish embryos, but no antifungal efficacy in infected mice, which may have been a result of low bioavailability. On the other hand, the association of DOD + NLS was beneficial and resulted in lower toxicity in lung fibroblasts and zebrafish embryos. In addition, NLS + DOD promoted a significant reduction in the fungal burden of mice lungs and could be a potential therapeutic option against PCM.-
Formato: dc.format630-636-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Pharmaceutics-
Relação: dc.relation1,172-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectAntifungal compound-
Palavras-chave: dc.subjectIn vivo models-
Palavras-chave: dc.subjectLipid nanoparticles-
Palavras-chave: dc.subjectParacoccidioides sp.-
Palavras-chave: dc.subjectSystemic mycosis-
Título: dc.titlePotential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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