Biopolymer-based membranes associated with osteogenic growth peptide for guided bone regeneration

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSaska, Sybele-
Autor(es): dc.creatorPigossi, Suzane C-
Autor(es): dc.creatorOliveira, Guilherme J. P. L.-
Autor(es): dc.creatorTeixeira, Lucas N.-
Autor(es): dc.creatorCapela, Marisa V.-
Autor(es): dc.creatorGonçalves, Andreia-
Autor(es): dc.creatorDe Oliveira, Paulo T.-
Autor(es): dc.creatorMessaddeq, Younès-
Autor(es): dc.creatorRibeiro, Sidney J. L.-
Autor(es): dc.creatorGaspar, Ana Maria Minarelli-
Autor(es): dc.creatorMarchetto, Reinaldo-
Data de aceite: dc.date.accessioned2021-03-11T00:57:10Z-
Data de disponibilização: dc.date.available2021-03-11T00:57:10Z-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2018-03-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1088/1748-605X/aaaa2d-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/179797-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/179797-
Descrição: dc.descriptionBarrier membranes for guided bone regeneration (GBR) mainly promote mechanical maintenance of bone defect space and induce osteopromotion. Additionally, biopolymer-based membranes may provide greater bioactivity and biocompatibility due to their similarity to extracellular matrix (ECM). In this study, biopolymers-based membranes from bacterial cellulose (BC) and collagen (COL) associated with osteogenic growth peptide (OGP(10-14)) were evaluated to determine in vitro osteoinductive potential in early osteogenesis; moreover, histological study was performed to evaluate the BC-COL OGP(10-14) membranes on bone healing after GBR in noncritical defects in rat femur. The results showed that the BC-COL and BC-COL OGP(10-14) membranes promoted cell proliferation and alkaline phosphatase activity in osteoblastic cell cultures. However, ECM mineralization was similar between cultures grown on BC OGP(10-14) and BC-COL OGP(10-14) membranes. In vivo results showed that all the membranes tested, including the peptide-free BC membrane, promoted better bone regeneration than control group. Furthermore, the BC-COL OGP(10-14) membranes induced higher radiographic density in the repaired bone than the other groups at 1, 4 and 16 weeks. Histomorphometric analyses revealed that the BC-COL OGP(10-14) induced higher percentage of bone tissue in the repaired area at 2 and 4 weeks than others membranes. In general, these biopolymer-based membranes might be potential candidates for bone regeneration applications.-
Idioma: dc.languageen-
Relação: dc.relationBiomedical Materials (Bristol)-
Relação: dc.relation0,768-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectbacterial cellulose-
Palavras-chave: dc.subjectbarrier membrane-
Palavras-chave: dc.subjectcollagen-
Título: dc.titleBiopolymer-based membranes associated with osteogenic growth peptide for guided bone regeneration-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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