Effect of preeclampsia on human milk cytokine levels

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorFreitas, Natália Alves de-
Autor(es): dc.creatorSantiago, Luiza Tavares Carneiro-
Autor(es): dc.creatorKurokawa, Cilmery Suemi-
Autor(es): dc.creatorMeira Junior, José Donizeti de-
Autor(es): dc.creatorCorrente, José Eduardo-
Autor(es): dc.creatorRugolo, Ligia Maria Suppo de Souza-
Data de aceite: dc.date.accessioned2021-03-11T00:50:46Z-
Data de disponibilização: dc.date.available2021-03-11T00:50:46Z-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2018-01-29-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/14767058.2018.1429395-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/177106-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/177106-
Descrição: dc.descriptionIntroduction: Preeclampsia (PE) is a systemic inflammatory disease, and its effect on human milk immune components is poorly understood. Objective: To investigate whether PE affects human milk cytokine levels. Methods: This was a prospective observational study involving mothers diagnosed with PE and with singleton pregnancy with no fetal malformation. The following cases were excluded: diabetes, chorioamnionitis, use of illicit drugs and alcohol, mastitis and congenital infection. In total, 228 mothers were studied and divided into two groups matched by gestational age: PE (n = 114) and normotensive (control, n = 114). Colostrum was collected from 24–72 hours postpartum, and mature milk was collected at the end of the first month. Cytokines (IL-1β, IL-6, IL-8, IL-10, IL-12, and TNF-α) were measured using flow cytometry. A generalized linear model with a gamma distribution was used to analyze the differences between groups versus time interaction. Results: The mean gestational age was 36 weeks. Increased IL-1 and IL-6 levels and reduced IL-12 levels in the colostrum were detected in PE, while in the mature milk, the IL-6 and IL-8 levels were lower than those of the control group. Conclusions: PE is associated with increased levels of inflammatory cytokines in colostrum and decreased levels in mature milk.-
Formato: dc.format1-5-
Idioma: dc.languageen-
Relação: dc.relationJournal of Maternal-Fetal and Neonatal Medicine-
Relação: dc.relation0,714-
Relação: dc.relation0,714-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectcolostrum-
Palavras-chave: dc.subjectcytokines-
Palavras-chave: dc.subjecthuman milk-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectPreeclampsia-
Título: dc.titleEffect of preeclampsia on human milk cytokine levels-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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