Gene-gene interactions in the NAMPT pathway, plasma visfatin/NAMPT levels, and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorLuizon, M. R.-
Autor(es): dc.creatorPalei, A. C.T.-
Autor(es): dc.creatorBelo, V. A.-
Autor(es): dc.creatorAmaral, L. M.-
Autor(es): dc.creatorLacchini, R.-
Autor(es): dc.creatorDuarte, G.-
Autor(es): dc.creatorCavalli, R. C.-
Autor(es): dc.creatorSandrim, V. C.-
Autor(es): dc.creatorTanus-Santos, J. E.-
Data de aceite: dc.date.accessioned2021-03-11T00:50:17Z-
Data de disponibilização: dc.date.available2021-03-11T00:50:17Z-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2017-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/tpj.2016.35-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/176921-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/176921-
Descrição: dc.descriptionNicotinamide phosphorybosil transferase (NAMPT) polymorphisms affect visfatin/NAMPT levels and may affect the responsiveness to therapy in hypertensive disorders of pregnancy. We examined whether NAMPT polymorphisms (rs1319501 T>C and rs3801266 A>G), or haplotypes, and gene-gene interactions in the NAMPT pathway affect plasma visfatin/NAMPT levels and the response to antihypertensive therapy in 205 patients with preeclampsia (PE) and 174 patients with gestational hypertension. We also studied 207 healthy pregnant controls. Plasma visfatin/NAMPT levels were measured by ELISA. Non-responsive PE patients with the TC+CC genotypes for the rs1319501 T>C, and with the AG+GG genotypes for the rs3801266 A>G polymorphism had lower and higher visfatin/NAMPT levels, respectively. The ' C, A' haplotype was associated with response to antihypertensive therapy, and with lower visfatin/NAMPT levels in PE. Interactions among NAMPT, TIMP-1 and MMP-2 genotypes were associated with PE and with lack of response to antihypertensive therapy in PE. Our results suggest that NAMPT polymorphisms affect plasma visfatin/NAMPT levels in nonresponsive PE patients, and that gene-gene interactions in the NAMPT pathway not only promote PE but also decrease the response to antihypertensive therapy in PE.-
Formato: dc.format427-434-
Idioma: dc.languageen-
Relação: dc.relationPharmacogenomics Journal-
Relação: dc.relation1,320-
Direitos: dc.rightsclosedAccess-
Título: dc.titleGene-gene interactions in the NAMPT pathway, plasma visfatin/NAMPT levels, and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.