Heart rate variability in individuals with Down syndrome – A systematic review and meta-analysis

Registro completo de metadados
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCarvalho, Tatiana Dias de-
Autor(es): dc.creatorMassetti, Thais-
Autor(es): dc.creatorSilva, Talita Dias da-
Autor(es): dc.creatorCrocetta, Tânia Brusque-
Autor(es): dc.creatorGuarnieri, Regiani-
Autor(es): dc.creatorVanderlei, Luiz Carlos Marques-
Autor(es): dc.creatorMonteiro, Carlos Bandeira de Mello-
Autor(es): dc.creatorGarner, David M.-
Autor(es): dc.creatorFerreira, Celso-
Data de aceite: dc.date.accessioned2021-03-11T00:48:51Z-
Data de disponibilização: dc.date.available2021-03-11T00:48:51Z-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2018-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.autneu.2018.05.006-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/176328-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/176328-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionProcesso FAPESP: 2010/18005-0-
Descrição: dc.descriptionIntroduction: Down syndrome (DS) results in many changes, including dysfunction in cardiac autonomic modulation. Heart rate variability (HRV) analysis evaluates the autonomic function and it is a predictor of adverse cardiovascular events. Objective: To present results of a systematic review and a meta-analysis about heart rate variability in individuals with DS. Method: A systematic review was performed on PubMed, PubMed Central and Web of science databases. We included articles that exhibited all the terms: “Down Syndrome” “heart rate variability” “autonomic nervous system” “autonomic dysfunction” and “cardiac autonomic modulation”. We conducted the meta-analysis to compare “DS” to “controls” during rest. Random effects models were used, as were appropriate tests for heterogeneity. Results: From 271 studies, 13 were included in our review. These are conducted with volunteers from a wide age range, of either gender, and not taking medications. Meta-analysis displayed that there were no significant differences between the groups at rest, except the RMSSD, which revealed a significant (Z = −2.80, p = 0.005) main effect (Hedge's g = −0.55, 95% CI [−0.93; −0.16]), indicating difference in individuals with DS compared with controls. Conclusion: There is autonomic dysfunction in individuals with DS, which may or may not be expressed at rest, but it is usually demonstrated in an autonomic task. Meta-analysis specified that there was no significant alteration between DS and the controls during rest, except RMSSD index which was lower in DS than controls. PROSPERO: CRD42017068647.-
Formato: dc.format23-33-
Idioma: dc.languageen-
Relação: dc.relationAutonomic Neuroscience: Basic and Clinical-
Relação: dc.relation0,902-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subject“Autonomic nervous system”-
Palavras-chave: dc.subject“Cardiac autonomic modulation”-
Palavras-chave: dc.subject“Down syndrome”-
Palavras-chave: dc.subject“Meta-analysis”-
Palavras-chave: dc.subject“Systematic review”-
Título: dc.titleHeart rate variability in individuals with Down syndrome – A systematic review and meta-analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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