Chagas disease pharmacotherapy and its chemical structure activity relationship

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorScarim, Cauê Benito-
Autor(es): dc.creatorChiba, Diego Eidy-
Autor(es): dc.creatorBosquesi, Priscila Longhin-
Autor(es): dc.creatordos Santos, Jean Leandro-
Autor(es): dc.creatorChin, Chung Man-
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Descrição: dc.descriptionTherapeutic arsenal currently available for Chagas disease is restricted in only two drugs, nifurtimox and benznidazole, since 1960s and 1970s, respectively. Despite the efforts to develop new drugs, until now, no new drugs were approved. This chapter describes the history of the two drugs used, as well as their mechanism of action, toxicity and relation-structure activity (SAR). In addition, the chapter addresses new therapies in clinical research, and those which are involved in programs (consortia) to develop new treatments for Chagas' disease.-
Formato: dc.format117-135-
Idioma: dc.languageen-
Relação: dc.relationChagas Disease: Prevalence, Diagnosis and Treatment Options-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectAction mechanism-
Palavras-chave: dc.subjectBenznidazole-
Palavras-chave: dc.subjectChagas' disease-
Palavras-chave: dc.subjectNufurtimox-
Palavras-chave: dc.subjectStructure activity relationship-
Palavras-chave: dc.subjectT. cruzi-
Título: dc.titleChagas disease pharmacotherapy and its chemical structure activity relationship-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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