Oxidative stress in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis: Possible association with major depressive disorder?

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Araújo Filho, Gerardo Maria-
Autor(es): dc.creatorMartins, Denise Poltronieri-
Autor(es): dc.creatorLopes, Angélica Marta-
Autor(es): dc.creatorde Jesus Brait, Beatriz-
Autor(es): dc.creatorFurlan, Ana Eliza Romano-
Autor(es): dc.creatorOliveira, Camila Ive Ferreira-
Autor(es): dc.creatorMarques, Lucia Helena Neves-
Autor(es): dc.creatorSouza, Dorotéia Rossi Silva-
Autor(es): dc.creatorde Almeida, Eduardo Alves-
Data de aceite: dc.date.accessioned2021-03-11T00:47:38Z-
Data de disponibilização: dc.date.available2021-03-11T00:47:38Z-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2018-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.yebeh.2017.12.025-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/175817-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/175817-
Descrição: dc.descriptionFaculdade de Medicina de São José do Rio Preto-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFaculdade de Medicina de São José do Rio Preto: 110400-
Descrição: dc.descriptionCNPq: 443742/2014-6-
Descrição: dc.descriptionObjective: The objective was to evaluate the genetic and biochemical profiles associated with oxidative stress (OS) in patients with temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS) and a healthy control group, and also to verify the possible existence of association between OS markers and psychiatric disorders (PD) in group with TLE-MTS. Methods: Forty-six patients with refractory TLE-MTS and 112 healthy controls were included. Psychiatric evaluation occurred through Diagnostical and Statistical Manual of Mental Disorders (DSM-5) criteria. A peripheral blood sample was collected for analysis of glutathione S-transferase (GST) T1/M1 polymorphisms and serum levels of malondialdehyde (MDA) and antioxidant capacity equivalent to the trolox (TEAC), serum markers of OS. Student's t-test, Fisher's exact test, Chi-square test, and Analysis of Variance (ANOVA) were used, with a significance level of P < 0.05. Results: The PD were observed in 27 patients of the group with TLE-MTS (58.6%); major depressive disorder (MDD) was the most frequent. Serum levels of MDA (P < 0.0001) and TEAC (P < 0.0001) were higher in group with TLE-MTS. When patients with MDD were compared with patients without PD, significant differences were observed between MDA (P = 0.002) and TEAC (P = 0.003) serum levels. Patients with TLE-MTS and MDD presented higher levels when compared with patients with TLE-MTS without PD and with another PD except MDD. Conclusions: The present study observed significantly higher serum levels of MDA and of TEAC in patients with refractory TLE-MTS in comparison with the control group. The MDD was observed as an important issue associated with higher OS levels in refractory TLE-MTS. Further studies are needed to investigate the association of OS, TLE-MTS, and PD.-
Formato: dc.format191-196-
Idioma: dc.languageen-
Relação: dc.relationEpilepsy and Behavior-
Relação: dc.relation1,131-
Relação: dc.relation1,131-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectMajor depressive disorder-
Palavras-chave: dc.subjectOxidative stress markers-
Palavras-chave: dc.subjectRefractory epilepsy-
Palavras-chave: dc.subjectTemporal lobe epilepsy-
Título: dc.titleOxidative stress in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis: Possible association with major depressive disorder?-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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