Topical nitric oxide releasing nanoparticles are effective in a murine model of dermal Trichophyton rubrum dermatophytosis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMordorski, Breanne-
Autor(es): dc.creatorCosta-Orlandi, Caroline Barcelos-
Autor(es): dc.creatorBaltazar, Ludmila M.-
Autor(es): dc.creatorCarreño, Leandro J.-
Autor(es): dc.creatorLandriscina, Angelo-
Autor(es): dc.creatorRosen, Jamie-
Autor(es): dc.creatorNavati, Mahantesh-
Autor(es): dc.creatorMendes-Giannini, Maria Jose Soares-
Autor(es): dc.creatorFriedman, Joel M.-
Autor(es): dc.creatorNosanchuk, Joshua D.-
Autor(es): dc.creatorFriedman, Adam J.-
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Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionCNPq: 150261/2016-0-
Descrição: dc.descriptionCAPES: 99999.007910/2014-02-
Descrição: dc.descriptionSystemic therapies are preferred for treating dermal dermatophytosis due to inadequate penetration of topical agents. However, systemic antifungals are associated with off-target effects and limited tissue penetration, and antimicrobial resistance is a growing concern. To address this, we investigated topical nitric oxide-releasing nanoparticles (NO-np), which have been used against superficial fungal infections and bacterial abscesses. In addition to enhanced penetration and permeation conferred by nanoparticles, nitric oxide, a broad-spectrum multi-mechanistic antimicrobial agent, offers decreased likelihood of resistance development. In the current study, NO-np inhibited Trichophyton rubrum in vitro, as well as in a murine model of dermal dermatophytosis. In mice, NO-np reduced fungal burden after three days, with complete clearance after seven. Furthermore, NO-np decreased tissue IL-2, 6, 10 and TNFα, indicating earlier attenuation of the host inflammatory response and decreased tissue morbidity. Thus, topical NO-np represent an attractive alternative to systemic therapy against dermal T. rubrum infection.-
Formato: dc.format2267-2270-
Idioma: dc.languageen-
Relação: dc.relationNanomedicine: Nanotechnology, Biology, and Medicine-
Relação: dc.relation1,743-
Relação: dc.relation1,743-
Direitos: dc.rightsopenAccess-
Título: dc.titleTopical nitric oxide releasing nanoparticles are effective in a murine model of dermal Trichophyton rubrum dermatophytosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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