Tumor necrosis factor receptor 2 as a possible marker of COPD in smokers and ex-smokers

Registro completo de metadados
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCaram, Laura Miranda de Oliveira-
Autor(es): dc.creatorFerrari, R.-
Autor(es): dc.creatorNogueira, D. L.-
Autor(es): dc.creatorOliveira, M. R.M.-
Autor(es): dc.creatorFrancisqueti, F. V.-
Autor(es): dc.creatorTanni, S. E.-
Autor(es): dc.creatorCorrêa, C. R.-
Autor(es): dc.creatorGodoy, I.-
Data de aceite: dc.date.accessioned2021-03-11T00:45:23Z-
Data de disponibilização: dc.date.available2021-03-11T00:45:23Z-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2017-07-07-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2147/COPD.S138558-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/174927-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/174927-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionProcesso FAPESP: 2012/22321-0-
Descrição: dc.descriptionIntroduction: Oxidative stress and systemic inflammation are higher in smokers and patients with COPD; however, markers that may help differentiate between smokers and patients with COPD have not yet been identified. We hypothesized that tumor necrosis factor-alpha receptor (TNFR) and soluble form of the receptor for advanced glycation end products (sRAGE) can be indicators of COPD in asymptomatic patients. Patients and methods: We evaluated 32 smokers (smoking history >10 pack-years), 32 patients with mild/moderate COPD (smokers and ex-smokers), and 32 never smokers. Concentrations of C-reactive protein (CRP), interleukin (IL)-6, TNFR1 and TNFR2, advanced glycation end products (AGEs), and the sRAGE were measured in serum. Results: There were higher CRP and AGEs concentrations in smokers and in patients with COPD (P<0.001 and P=0.01, respectively) compared to controls, without statistical difference between smokers and patients with COPD. Concentrations of sRAGE, IL-6, and TNFR1 did not differ between study groups. TNFR2 was significantly higher in patients with COPD than in smokers (P=0.004) and controls (P=0.004), and the presence of COPD (P=0.02) and CRP (P=0.001) showed a positive association with TNFR2. Positive associations for smoking (P=0.04), CRP (P=0.03), and IL-6 (P=0.03) with AGEs were also found. The interaction variable (smoking × COPD) showed a positive association with IL-6. Conclusion: Our data suggest that TNFR2 may be a possible marker of COPD in asymptomatic smokers and ex-smokers. Although smokers and patients with early COPD presented other increased systemic inflammation markers (eg, CRP) and oxidative stress (measured by AGEs), they did not differentiate smokers from COPD.-
Formato: dc.format2015-2021-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of COPD-
Relação: dc.relation1,395-
Relação: dc.relation1,395-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectChronic obstructive pulmonary disease-
Palavras-chave: dc.subjectInflammation mediators-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectSmoking-
Título: dc.titleTumor necrosis factor receptor 2 as a possible marker of COPD in smokers and ex-smokers-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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