Noradrenaline and dobutamine effects on the volume expansion with normal saline in rabbits subjected to hemorrhage

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRamalho, Gualter Lisboa-
Autor(es): dc.creatorVane, Matheus Fachini-
Autor(es): dc.creatorLima, Luciana Cavalcanti-
Autor(es): dc.creatorVane, Lucas Fachini-
Autor(es): dc.creatorAmorim, Rosa Beatriz-
Autor(es): dc.creatorDomingues, Maria Aparecida-
Autor(es): dc.creatorde Moraes, José Mariano Soares-
Autor(es): dc.creatorde Carvalho, Lídia Raquel-
Autor(es): dc.creatorTanaka, Pedro Paulo-
Autor(es): dc.creatorVane, Luiz Antonio-
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Descrição: dc.descriptionPURPOSE: To evaluate the effects of dobutamine (DB), noradrenaline (NA), and their combination (NADB), on volume retention in rabbits submitted to hemorrhage. METHODS: Thirty six rabbits were randomly divided into 6 groups: SHAM, Control, Saline, DB, NA, DB+NA. All the animals, except for SHAM, were subjected to hemorrhage of 25% of the calculated blood volume. Control animals were replaced with their own blood. The other groups received NSS 3 times the volume withdrawn. The intravascular retention, hematocrit, diuresis, central venous pressure, mean arterial pressure, NGAL, dry-to-wet lung weight ratio (DTWR) and the lung and kidney histology were analyzed. RESULTS: Replacement with NSS and NA, DB or NA+DB did not produce differences in the intravascular retention. After hemorrhage, the animals presented a significant decrease in the MAP and CVP, which were maintained until volume replacement. Regarding NGAL, dry-to-wet-lung-weight ratio, lung and kidney histology, there were no statistical differences between the groups. CONCLUSION: The use of noradrenaline, dobutamine or their combination did not increase the intravascular retention of volume after normal saline infusion.-
Formato: dc.format621-628-
Idioma: dc.languageen-
Relação: dc.relationActa Cirurgica Brasileira-
Relação: dc.relation0,395-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectCatecholamines-
Palavras-chave: dc.subjectHemorrhage-
Palavras-chave: dc.subjectPlasma volume-
Palavras-chave: dc.subjectRabbits-
Título: dc.titleNoradrenaline and dobutamine effects on the volume expansion with normal saline in rabbits subjected to hemorrhage-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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