Melatonin and IL-25 modulate apoptosis and angiogenesis mediators in metastatic (CF-41) and non-metastatic (CMT-U229) canine mammary tumour cells

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGelaleti, G. B.-
Autor(es): dc.creatorBorin, T. F.-
Autor(es): dc.creatorMaschio-Signorini, L. B.-
Autor(es): dc.creatorMoschetta, M. G.-
Autor(es): dc.creatorHellmén, E.-
Autor(es): dc.creatorViloria-Petit, A. M.-
Autor(es): dc.creatorZuccari, D. A.P.C.-
Data de aceite: dc.date.accessioned2021-03-11T00:32:16Z-
Data de disponibilização: dc.date.available2021-03-11T00:32:16Z-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2017-12-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/vco.12303-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/169587-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/169587-
Descrição: dc.descriptionUniversity of Guelph-
Descrição: dc.descriptionBackground: Melatonin has oncostatic actions and IL-25 is active in inflammatory processes that induce apoptosis in tumor cells. Aim: The aim of this study was to evaluate melatonin and IL-25 in metastatic (CF-41) and non-metastatic (CMT-U229) canine mammary tumor cells cultured as monolayers and tridimensional structures. Materials and Methods: The cells were treated with melatonin, IL-25 and IL-17B silencing gene and performed cell viability, gene and protein expression of caspase-3 and VEGFA (Vascular endothelial growth factor A) and an apoptosis membrane protein array. Results: Treatment with 1 mM of melatonin reduced cell viability of both tumor cell lines, all treatments alone and combined significantly increased caspase-3 cleaved and proteins involved in the apoptotic pathway and reduced pro-angiogenic VEGFA, confirming the effectiveness of these potential promising treatments. Conclusion: This is the first study evaluating the potential use of these strategies in CF-41 and CMT-U229 cell lines and together encourages subsequent in vitro and in vivo studies for further exploration of clinical applications.-
Formato: dc.format1572-1584-
Idioma: dc.languageen-
Relação: dc.relationVeterinary and Comparative Oncology-
Relação: dc.relation0,946-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectangiogenesis-
Palavras-chave: dc.subjectapoptosis-
Palavras-chave: dc.subjectcanine-
Palavras-chave: dc.subjectinterleukin-25-
Palavras-chave: dc.subjectmammary tumour cells-
Palavras-chave: dc.subjectmelatonin-
Título: dc.titleMelatonin and IL-25 modulate apoptosis and angiogenesis mediators in metastatic (CF-41) and non-metastatic (CMT-U229) canine mammary tumour cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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