A simple method to produce 2D and 3D microfluidic paper-based analytical devices for clinical analysis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Oliveira, Ricardo A.G.-
Autor(es): dc.creatorCamargo, Fiamma-
Autor(es): dc.creatorPesquero, Naira C.-
Autor(es): dc.creatorFaria, Ronaldo Censi-
Data de aceite: dc.date.accessioned2021-03-11T00:31:42Z-
Data de disponibilização: dc.date.available2021-03-11T00:31:42Z-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2017-03-08-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.aca.2017.01.002-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/169352-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/169352-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCNPq: 140484/2013-2-
Descrição: dc.descriptionProcesso FAPESP: 2015/19890-1-
Descrição: dc.descriptionCNPq: 427727/2016-2-
Descrição: dc.descriptionThis paper describes the fabrication of 2D and 3D microfluidic paper-based analytical devices (μPADs) for monitoring glucose, total protein, and nitrite in blood serum and artificial urine. A new method of cutting and sealing filter paper to construct μPADs was demonstrated. Using an inexpensive home cutter printer soft cellulose-based filter paper was easily and precisely cut to produce pattern hydrophilic microchannels. 2D and 3D μPADs were designed with three detection zones each for the colorimetric detection of the analytes. A small volume of samples was added to the μPADs, which was photographed after 15 min using a digital camera. Both μPADs presented an excellent analytical performance for all analytes. The 2D device was applied in artificial urine samples and reached limits of detection (LODs) of 0.54 mM, 5.19 μM, and 2.34 μM for glucose, protein, and nitrite, respectively. The corresponding LODs of the 3D device applied for detecting the same analytes in artificial blood serum were 0.44 mM, 1.26 μM, and 4.35 μM.-
Formato: dc.format40-46-
Idioma: dc.languageen-
Relação: dc.relationAnalytica Chimica Acta-
Relação: dc.relation1,512-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectColorimetric detection-
Palavras-chave: dc.subjectLow-cost diagnostics-
Palavras-chave: dc.subjectPaper-based analytical devices-
Palavras-chave: dc.subjectPoint-of-care devices-
Título: dc.titleA simple method to produce 2D and 3D microfluidic paper-based analytical devices for clinical analysis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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