The prodrug approach: A successful tool for improving drug solubility

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorJornada, Daniela Hartmann-
Autor(es): dc.creatorDos Santos Fernandes, Guilherme Felipe-
Autor(es): dc.creatorChiba, Diego Eidy-
Autor(es): dc.creatorDe Melo, Thais Regina Ferreira-
Autor(es): dc.creatorDos Santos, Jean Leandro-
Autor(es): dc.creatorChung, Man Chin-
Data de aceite: dc.date.accessioned2021-03-11T00:31:17Z-
Data de disponibilização: dc.date.available2021-03-11T00:31:17Z-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2016-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/molecules21010042-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/169189-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/169189-
Descrição: dc.descriptionProdrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug development. This review aims to describe recent advances in the improvement of solubility via the prodrug approach. The main chemical carriers and examples of successful strategies will be discussed, highlighting the advances of this field in the last ten years.-
Idioma: dc.languageen-
Relação: dc.relationMolecules-
Relação: dc.relation0,855-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectMolecular modification-
Palavras-chave: dc.subjectProdrug-
Palavras-chave: dc.subjectSolubility-
Palavras-chave: dc.subjectSolubility of prodrugs-
Palavras-chave: dc.subjectWater-soluble prodrugs-
Título: dc.titleThe prodrug approach: A successful tool for improving drug solubility-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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