Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSeiva, Fabio R. F.-
Autor(es): dc.creatorChuffa, Luiz Gustavo A.-
Autor(es): dc.creatorBraga, Camila Pereira-
Autor(es): dc.creatorAmorim, Joao Paulo A.-
Autor(es): dc.creatorFernandes, Ana Angelica H.-
Data de aceite: dc.date.accessioned2021-03-10T17:08:40Z-
Data de disponibilização: dc.date.available2021-03-10T17:08:40Z-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2012-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.fct.2012.07.009-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/16909-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/16909-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionProcesso FAPESP: 02/03359-5-
Descrição: dc.descriptionWe reported the effects of quercetin on metabolic and hormonal profile as well as serum antioxidant activities in a model of MSG (monosodium glutamate)-induced obesity. Rats were divided into 4 groups: MSG group, submitted to neonatal treatment with high doses of MSG, administrated subcutaneously during 10 days, from 2 day-old; control groups, which received the same volume of saline. After completing 30 day-old, these groups were subdivided into 4 groups: control and MSG groups treated and non-treated with quercetin at doses of 75 mg/kg body weight (i.p.) over 42 days. BW gain and food consumption were higher in MSG treated rats and quercetin significantly reduced BW by 25%. While MSG increased triacylglycerol, total cholesterol and fractions, and reduced HDL concentrations, administration of quercetin normalized HDL-cholesterol and reduced others lipids. Insulin, leptin, glucose and creatinine levels were raised in MSG-treated rats and reduced after quercetin treatment. Alanine transaminase, aspartate transaminase, lactate dehydrogenase and alkaline phosphatase activities were lower after MSG-quercetin combination compared to rats given only MSG. MSG-quercetin combination augmented total protein and urea levels as well as glutathione peroxidase and superoxide dismutase activities in contrast to MSG-treated animals. Quercetin normalized serum lipid and glucose profile and minimized the MSG-related toxic effects, which was associated to its antioxidant properties. (C) 2012 Elsevier Ltd. All rights reserved.-
Formato: dc.format3556-3561-
Idioma: dc.languageen-
Publicador: dc.publisherPergamon-Elsevier B.V. Ltd-
Relação: dc.relationFood and Chemical Toxicology-
Relação: dc.relation3.977-
Relação: dc.relation1,144-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectMonosodium glutamate-
Palavras-chave: dc.subjectLipid profile-
Palavras-chave: dc.subjectMetabolism-
Palavras-chave: dc.subjectQuercetin-
Palavras-chave: dc.subjectHepatoprotection-
Palavras-chave: dc.subjectAntioxidant defenses-
Título: dc.titleQuercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations-
Tipo de arquivo: dc.typelivro digital-
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