Treatment with Parkinsonia aculeata combats insulin resistance-induced oxidative stress through the increase in PPARγ/CuZn-SOD axis expression in diet-induced obesity mice

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorAraújo, Tiago Gomes-
Autor(es): dc.creatorOliveira, Alexandre Gabarra-
Autor(es): dc.creatorVecina, Juliana Falcato-
Autor(es): dc.creatorMarin, Rodrigo Miguel-
Autor(es): dc.creatorFranco, Eryvelton Souza-
Autor(es): dc.creatorAbdalla Saad, Mario J.-
Autor(es): dc.creatorde Sousa Maia, Maria Bernadete-
Data de aceite: dc.date.accessioned2021-03-11T00:30:09Z-
Data de disponibilização: dc.date.available2021-03-11T00:30:09Z-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2018-12-11-
Data de envio: dc.date.issued2016-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11010-016-2753-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/168773-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/168773-
Descrição: dc.descriptionParkinsonia aculeata L. (Caesalpiniaceae) is a traditional ethnomedicine and has been used for the empiric treatment of hyperglycemia, without scientific background. Mechanistic analyses at molecular level from the antioxidant mechanism observed by P. aculeata are required. Herein the effects of the treatment by hydroethanolic extract partitioned with ethyl acetate of P. aculeata aerial parts (HEPa/EtOAc) in mice fed a high-fat diet that share many obesity phenotypes with humans were evaluated. The animals were treated orally with HEPa/EtOAc (125 and 250 mg/kg/day) and pioglitazone (5 mg/kg/day), for 16 days. After the treatment, HEPa/EtOAc reduced fasting serum glucose and insulin levels, as well as homeostasis model assessment for insulin resistance. In addition, an improvement in glucose intolerance was also observed. Indeed, a reduction in the circulating levels of TNF-α and IL-6 was also observed. Furthermore, at molecular level, it was demonstrated that the HEPa/EtOAc treatment was able to improve these physiological parameters, through the activation of peroxisome proliferator-activated receptor γ (PPARγ) per si, as well as the enhancement of antioxidant mechanism by an increase in PPARγ/Cu2+, Zn2+-superoxide dismutase (CuZn-SOD) axis expression in liver and adipose tissue. In sum, P. aculeata is effective to improve insulin resistance in a mouse model of obesity and this effect seems to involve the antioxidant and anti-inflammatory mechanisms through the increase in PPARγ/CuZn-SOD axis expression.-
Formato: dc.format93-101-
Idioma: dc.languageen-
Relação: dc.relationMolecular and Cellular Biochemistry-
Relação: dc.relation1,003-
Relação: dc.relation1,003-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectAntioxidant-
Palavras-chave: dc.subjectCuZn-SOD-
Palavras-chave: dc.subjectFabaceae-
Palavras-chave: dc.subjectInsulin resistance-
Palavras-chave: dc.subjectObesity-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectParkinsonia aculeata-
Palavras-chave: dc.subjectPPARγ-
Título: dc.titleTreatment with Parkinsonia aculeata combats insulin resistance-induced oxidative stress through the increase in PPARγ/CuZn-SOD axis expression in diet-induced obesity mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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