Intestinal host defense outcome is dictated by PGE(2) production during efferocytosis of infected cells

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDejani, Naiara Naiana-
Autor(es): dc.creatorOrlando, Allan Botinhon-
Autor(es): dc.creatorNino, Victoria Eugenia-
Autor(es): dc.creatorPenteado, Leticia de Aquino-
Autor(es): dc.creatorVerdan, Felipe Fortino-
Autor(es): dc.creatorRibeiro Bazzano, Julia Miranda-
Autor(es): dc.creatorCodo, Ana Campos-
Autor(es): dc.creatorGuerta Salina, Ana Carolina-
Autor(es): dc.creatorSaraiva, Amanda Correia-
Autor(es): dc.creatorAvelar, Matheus Rossi-
Autor(es): dc.creatorSpolidorio, Luis Carlos-
Autor(es): dc.creatorSerezani, C. Henrique-
Autor(es): dc.creatorMedeiros, Alexandra Ivo-
Data de aceite: dc.date.accessioned2021-03-10T23:59:04Z-
Data de disponibilização: dc.date.available2021-03-10T23:59:04Z-
Data de envio: dc.date.issued2018-11-26-
Data de envio: dc.date.issued2018-11-26-
Data de envio: dc.date.issued2018-09-04-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1073/pnas.1722016115-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/164601-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/164601-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionProcesso FAPESP: FAPESP 11/17611-7-
Descrição: dc.descriptionProcesso FAPESP: 12/23580-0-
Descrição: dc.descriptionProcesso FAPESP: 14/03967-2-
Descrição: dc.descriptionProcesso FAPESP: 16/10964-5-
Descrição: dc.descriptionInflammatory responses are terminated by the clearance of dead cells, a process termed efferocytosis. A consequence of efferocytosis is the synthesis of the antiinflammatory mediators TGF-beta, PGE(2), and IL-10; however, the efferocytosis of infected cells favors Th17 responses by eliciting the synthesis of TGF-beta, IL-6, and IL-23. Recently, we showed that the efferocytosis of apoptotic Escherichia coli-infected macrophages by dendritic cells triggers PGE(2) production in addition to pro-Th17 cytokine expression. We therefore examined the role of PGE(2) during Th17 differentiation and intestinal pathology. The efferocytosis of apoptotic E. coli-infected cells by dendritic cells promoted high levels of PGE(2), which impaired IL-1R expression via the EP4-PKA pathway in T cells and consequently inhibited Th17 differentiation. The outcome of murine intestinal Citrobacter rodentium infection was dependent on the EP4 receptor. Infected mice treated with EP4 antagonist showed enhanced intestinal defense against C. rodentium compared with infected mice treated with vehicle control. Those results suggest that EP4 signaling during infectious colitis could be targeted as a way to enhance Th17 immunity and host defense.-
Formato: dc.formatE8469-E8478-
Idioma: dc.languageen-
Publicador: dc.publisherNatl Acad Sciences-
Relação: dc.relationProceedings Of The National Academy Of Sciences Of The United States Of America-
Relação: dc.relation6,092-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectefferocytosis-
Palavras-chave: dc.subjectinfected apoptotic cells-
Palavras-chave: dc.subjectprostaglandin E-2-
Palavras-chave: dc.subjectTh17 cells-
Palavras-chave: dc.subjectEP4-
Título: dc.titleIntestinal host defense outcome is dictated by PGE(2) production during efferocytosis of infected cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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