Occupational hazards, DNA damage, and oxidative stress on exposure to waste anesthetic gases

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorLucio, Lorena M. C.-
Autor(es): dc.creatorBraz, Mariana G.-
Autor(es): dc.creatorNascimento Junior, Paulo do-
Autor(es): dc.creatorBraz, Jose Reinaldo C.-
Autor(es): dc.creatorBraz, Leandro G.-
Data de aceite: dc.date.accessioned2021-03-10T23:57:02Z-
Data de disponibilização: dc.date.available2021-03-10T23:57:02Z-
Data de envio: dc.date.issued2018-11-26-
Data de envio: dc.date.issued2018-11-26-
Data de envio: dc.date.issued2018-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bjane.2017.07.002-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/163819-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/163819-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionProcesso FAPESP: 2013/21130-0-
Descrição: dc.descriptionCAPES: 14527-13-8-
Descrição: dc.descriptionBackground and objectives: The waste anesthetic gases (WAGs) present in the ambient air of operating rooms (OR), are associated with various occupational hazards. This paper intends to discuss occupational exposure to WAGs and its impact on exposed professionals, with emphasis on genetic damage and oxidative stress. Content: Despite the emergence of safer inhaled anesthetics, occupational exposure to WAGs remains a current concern. Factors related to anesthetic techniques and anesthesia workstations, in addition to the absence of a scavenging system in the OR, contribute to anesthetic pollution. In order to minimize the health risks of exposed professionals, several countries have recommended legislation with maximum exposure limits. However, developing countries still require measurement of WAGs and regulation for occupational exposure to WAGs. WAGs are capable of inducing damage to the genetic material, such as DNA damage assessed using the comet assay and increased frequency of micronucleus in professionals with long-term exposure. Oxidative stress is also associated with WAGs exposure, as it induces lipid peroxidation, oxidative damage in DNA, and impairment of the antioxidant defense system in exposed professionals. Conclusions: The occupational hazards related to WAGs including genotoxicity, mutagenicity and oxidative stress, stand as a public health issue and must be acknowledged by exposed personnel and responsible authorities, especially in developing countries. Thus, it is urgent to stablish maximum safe limits of concentration of WAGs in ORs and educational practices and protocols for exposed professionals. (C) 2017 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda.-
Formato: dc.format33-41-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationRevista Brasileira De Anestesiologia-
Relação: dc.relation0,320-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectInhaled anesthetics-
Palavras-chave: dc.subjectOccupational exposure-
Palavras-chave: dc.subjectEnvironment pollution-
Palavras-chave: dc.subjectGenotoxicity testing-
Palavras-chave: dc.subjectGenomic instability-
Palavras-chave: dc.subjectOxidative stress-
Título: dc.titleOccupational hazards, DNA damage, and oxidative stress on exposure to waste anesthetic gases-
Tipo de arquivo: dc.typelivro digital-
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