Transcription Factor Networks derived from Breast Cancer Stem Cells control the immune response in the Basal subtype

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSilveira, W. A. da-
Autor(es): dc.creatorPalma, P. V. B.-
Autor(es): dc.creatorSicchieri, R. D.-
Autor(es): dc.creatorVillacis, R. A. R.-
Autor(es): dc.creatorMandarano, L. R. M.-
Autor(es): dc.creatorOliveira, T. M. G.-
Autor(es): dc.creatorAntonio, H. M. R.-
Autor(es): dc.creatorAndrade, J. M.-
Autor(es): dc.creatorMuglia, V. F.-
Autor(es): dc.creatorRogatto, S. R.-
Autor(es): dc.creatorTheillet, C.-
Autor(es): dc.creatordu Manoir, S.-
Autor(es): dc.creatorTiezzi, D. G.-
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Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionINCa grant MOPRECLI-
Descrição: dc.descriptionINCa grant Role of cancer stem cells during metastatic progression of breast cancer-
Descrição: dc.descriptionComprehensive Cancer Center of Montpellier (SIRIC Montpellier-Cancer)-
Descrição: dc.descriptionProcesso FAPESP: 11/19758-5-
Descrição: dc.descriptionBreast cancer is the most common cancer in women worldwide and metastatic dissemination is the principal factor related to death by this disease. Breast cancer stem cells (bCSC) are thought to be responsible for metastasis and chemoresistance. In this study, based on whole transcriptome analysis from putative bCSC and reverse engineering of transcription control networks, we identified two networks associated with this phenotype. One controlled by SNAI2, TWIST1, BNC2, PRRX1 and TBX5 drives a mesenchymal or CSC-like phenotype. The second network is controlled by the SCML4, ZNF831, SP140 and IKZF3 transcription factors which correspond to immune response modulators. Immune response network expression is correlated with pathological response to chemotherapy, and in the Basal subtype is related to better recurrence-free survival. In patient-derived xenografts, the expression of these networks in patient tumours is predictive of engraftment success. Our findings point out a potential molecular mechanism underlying the balance between immune surveillance and EMT activation in breast cancer. This molecular mechanism may be useful to the development of new target therapies.-
Formato: dc.format13-
Idioma: dc.languageen-
Publicador: dc.publisherNature Publishing Group-
Relação: dc.relationScientific Reports-
Relação: dc.relation1,533-
Direitos: dc.rightsopenAccess-
Título: dc.titleTranscription Factor Networks derived from Breast Cancer Stem Cells control the immune response in the Basal subtype-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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