Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorTanikawa, Aline Aki-
Autor(es): dc.creatorTommasini Grotto, Rejane Maria-
Autor(es): dc.creatorSilva, Giovanni Faria-
Autor(es): dc.creatorFerrasi, Adriana Camargo-
Autor(es): dc.creatorRodrigues Sarnighausen, Valeria Cristina-
Autor(es): dc.creatorMoura Campos Pardini, Maria Ines de-
Data de aceite: dc.date.accessioned2021-03-10T23:53:38Z-
Data de disponibilização: dc.date.available2021-03-10T23:53:38Z-
Data de envio: dc.date.issued2018-11-26-
Data de envio: dc.date.issued2018-11-26-
Data de envio: dc.date.issued2017-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/0037-8682-0302-2016-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/162579-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/162579-
Descrição: dc.descriptionIntroduction: Transforming growth factor beta 1 (TGFB1) and platelet-derived growth factor (PDGF) are the main cytokines related to hepatic fibrogenesis. Methods: RNA isolated from the platelets and hepatic tissue of 43 HCV carriers was used for quantitative polymerase chain reaction to determine TGFB1, PDGFA, and PDGFB RNA expression. Results: The mRNA expression of PDGFA in platelets was significantly lower in the group with advanced fibrosis than in the group with early-stage fibrosis. TGFB1 was more frequently expressed in platelets than in hepatic tissue, which was different from PDGFB. Conclusions: A pathway mediated by overexpression of TGFB1 via PDGFA in megakaryocytes could be involved in the development of fibrosis.-
Formato: dc.format113-116-
Idioma: dc.languageen-
Publicador: dc.publisherSoc Brasileira Medicina Tropical-
Relação: dc.relationRevista Da Sociedade Brasileira De Medicina Tropical-
Relação: dc.relation0,658-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectHepatic fibrosis-
Palavras-chave: dc.subjectPDGF-
Palavras-chave: dc.subjectTGFB-
Título: dc.titlePlatelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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