Distinct mitochondrial HSP70 homologues conserved in various Leishmania species suggest novel biological functions

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCampos, Rodrigo M.-
Autor(es): dc.creatorNascimento, Mirna-
Autor(es): dc.creatorCandido Ferraz, J.-
Autor(es): dc.creatorPereira, Mariana M. C.-
Autor(es): dc.creatorRocha, Pollyanna O.-
Autor(es): dc.creatorThompson, Gloria M.-
Autor(es): dc.creatorCysne-Finkelstein, Lea-
Autor(es): dc.creatorFigueiredo, Regina C. B. Q.-
Autor(es): dc.creatorde Melo Neto, Osvaldo P.-
Data de aceite: dc.date.accessioned2021-03-10T17:06:37Z-
Data de disponibilização: dc.date.available2021-03-10T17:06:37Z-
Data de envio: dc.date.issued2013-09-30-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2013-09-30-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2008-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.molbiopara.2008.04.013-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/15994-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/15994-
Descrição: dc.descriptionWe report the identification of two distinct homologues of the 70-kDa mitochondrial heat shock protein (mtHSP70) from Leishmania chagasi/Leishmania infantum (Lc2.1 and Lc2.2). in Leishmania species, multiple genes encoding Lc2.2 are present whilst single genes encode Lc2.1. Strikingly, genes encoding Lc2.1-like proteins are absent from Trypanosoma species. Lc2.2 is characterized by a poly-glutamine rich C-terminus, absent from Lc2.1 or mtHSP70 homologues outside the trypanosomatids. Lc2.1 displays unique substitutions within its peptide-binding domain which modify amino acids strictly conserved in cytoplasmic and mitochondrial HSP70 proteins alike. Affinity purified antibodies recognize mainly a single protein in extracts from promastigotes/epimastigotes of various Leishmania/Trypanosoma species. Upon differentiation of Leishmania amazonensis into amastigotes a second protein (presumably Lc2.1) is induced and becomes the predominant mtHSP70 homologue expressed. Subcellular localization of these proteins was investigated and ratified a distribution throughout the mitochondrial matrix. Our results imply novel mtHSP70 functions which evolved within the genus Leishmania. (C) 2008 Elsevier B.V. All rights reserved.-
Formato: dc.format157-162-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationMolecular and Biochemical Parasitology-
Relação: dc.relation1.744-
Relação: dc.relation1,109-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectLeishmania chagasi-
Palavras-chave: dc.subjectheat shock proteins-
Palavras-chave: dc.subjectmtHSP70-
Palavras-chave: dc.subjectmitochondria-
Título: dc.titleDistinct mitochondrial HSP70 homologues conserved in various Leishmania species suggest novel biological functions-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.