Anti-inflammatory intestinal activity of Combretum duarteanum Cambess. in trinitrobenzene sulfonic acid colitis model

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMorais Lima, Gedson Rodrigues de-
Autor(es): dc.creatorFrota Machado, Flavia Danniele-
Autor(es): dc.creatorLucena Perico, Larissa-
Autor(es): dc.creatorMeira de Faria, Felipe-
Autor(es): dc.creatorLuiz-Ferreira, Anderson-
Autor(es): dc.creatorSouza Brito, Alba Regina Monteiro-
Autor(es): dc.creatorHelena Pellizzon, Cludia-
Autor(es): dc.creatorAkiko Hiruma-Lima, Claudia-
Autor(es): dc.creatorFechine Tavares, Josean-
Autor(es): dc.creatorBarbosa Filho, Jose Maria-
Autor(es): dc.creatorMaria Batista, Leonia-
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Descrição: dc.descriptionAIM To evaluate the anti-inflammatory intestinal effect of the ethanolic extract (EtOHE) and hexane phase (HexP) obtained from the leaves of Combretum duarteanum (Cd). METHODS Inflammatory bowel disease was induced using trinitrobenzenesulfonic acid in acute and relapsed ulcerative colitis in rat models. Damage scores, and biochemical, histological and immunohistochemical parameters were evaluated. RESULTS Both Cd-EtOHE and Cd-HexP caused significant reductions in macroscopic lesion scores and ulcerative lesion areas. The vegetable samples inhibited myeloperoxidase increase, as well as pro-inflammatory cytokines TNF-alpha and IL-1 beta. Anti-inflammatory cytokine IL-10 also increased in animals treated with the tested plant samples. The anti-inflammatory intestinal effect is related to decreased expression of cyclooxygenase-2, proliferating cell nuclear antigen, and an increase in superoxide dismutase. CONCLUSION The data indicate anti-inflammatory intestinal activity. The effects may also involve participation of the antioxidant system and principal cytokines relating to inflammatory bowel disease.-
Formato: dc.format1353-1366-
Idioma: dc.languageen-
Publicador: dc.publisherBaishideng Publishing Group Inc-
Relação: dc.relationWorld Journal Of Gastroenterology-
Relação: dc.relation1,409-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectCombretum duarteanum-
Palavras-chave: dc.subjectMedicinal plants-
Palavras-chave: dc.subjectCombretaceae-
Palavras-chave: dc.subjectInflammatory bowel disease-
Palavras-chave: dc.subjectAnti-inflammatory intestinal activity-
Título: dc.titleAnti-inflammatory intestinal activity of Combretum duarteanum Cambess. in trinitrobenzene sulfonic acid colitis model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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