Bone healing in critical-size defects treated with platelet-rich plasma activated by two different methods. A histologic and histometric study in rat calvaria

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMessora, M. R.-
Autor(es): dc.creatorNagata, Maria José Hitomi-
Autor(es): dc.creatorDornelles, Rita Cassia Menegati-
Autor(es): dc.creatorBomfim, Suely Regina Mogami-
Autor(es): dc.creatorFurlaneto, F. A. C.-
Autor(es): dc.creatorde Melo, L. G. N.-
Autor(es): dc.creatorDeliberador, T. M.-
Autor(es): dc.creatorBosco, Álvaro Francisco-
Autor(es): dc.creatorGarcia, Valdir Gouveia-
Autor(es): dc.creatorFucini, S. E.-
Data de aceite: dc.date.accessioned2021-03-10T17:03:45Z-
Data de disponibilização: dc.date.available2021-03-10T17:03:45Z-
Data de envio: dc.date.issued2013-09-30-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2013-09-30-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2008-12-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/j.1600-0765.2008.01084.x-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/14905-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/14905-
Descrição: dc.descriptionThe purpose of this study was to analyze histologically the influence of platelet-rich plasma (PRP) coagulated with two different activators on bone healing in surgically created critical-size defects (CSD) in rat calvaria.Forty-eight rats were divided into three groups: C, PRP-C and PRP-T. An 8 mm diameter CSD was created in the calvarium of each animal. In group C, the defect was filled by a blood clot only. In groups PRP-C and PRP-T, the defect was filled with PRP activated with either calcium chloride or thromboplastin solution, respectively. Each group was divided into two subgroups (n = 8 per subgroup) and killed at either 4 or 12 weeks postoperatively. Histologic and histometric analyses were performed. The amount of new bone formed was calculated as a percentage of the total area of the original defect. Percentage data were transformed into arccosine for statistical analysis (analysis of variance, Tukey's post hoc test, p < 0.05).No defect completely regenerated with bone. Group PRP-C had a statistically greater amount of bone formation than groups C and PRP-T at both time points of analysis. No statistically significant differences were observed between groups C and PRP-T.It can be concluded that the type of activator used to initiate PRP clot formation influences its biological effect on bone healing in CSD in rat calvaria.-
Formato: dc.format723-729-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-Blackwell Publishing, Inc-
Relação: dc.relationJournal of Periodontal Research-
Relação: dc.relation2.878-
Relação: dc.relation0,927-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectplatelet-rich plasma-
Palavras-chave: dc.subjectgrowth factor-
Palavras-chave: dc.subjectcoagulant-
Palavras-chave: dc.subjectbone regeneration-
Título: dc.titleBone healing in critical-size defects treated with platelet-rich plasma activated by two different methods. A histologic and histometric study in rat calvaria-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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