Effects of meperidine or saline on thermal, mechanical and electrical nociceptive thresholds in cats

Registro completo de metadados
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMillette, Valerie M.-
Autor(es): dc.creatorSteagall, Paulo V. M.-
Autor(es): dc.creatorDuke-Novakovski, Tanya-
Autor(es): dc.creatorLivingston, Alex J.-
Data de aceite: dc.date.accessioned2021-03-10T17:00:04Z-
Data de disponibilização: dc.date.available2021-03-10T17:00:04Z-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2008-11-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/j.1467-2995.2008.00419.x-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/13606-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/13606-
Descrição: dc.descriptionObjective To measure cutaneous electrical nociceptive thresholds in relation to known thermal and mechanical stimulation for nociceptive threshold detection in cats.Study design Prospective, blinded, randomized cross-over study with 1-week washout interval.Animals Eight adult cats [bodyweight 5.1 +/- 1.8 kg (mean + SD)].Methods Mechanical nociceptive thresholds were tested using a step-wise manual inflation of a modified blood pressure bladder attached to the cat's thoracic limb. Thermal nociceptive thresholds were measured by increasing the temperature of a probe placed on the thorax. The electrical nociceptive threshold was tested using an escalating current from a constant current generator passed between electrodes placed on the thoracic region. A positive response (threshold) was recorded when cats displayed any or all of the following behaviors: leg shake, head turn, avoidance, or vocalization. Four baseline readings were performed before intramuscular injection of meperidine (5 mg kg(-1)) or an equal volume of saline. Threshold recordings with each modality were made at 15, 30, 45, 60, 90, and 120 minutes post-injection. Data were analyzed using ANOVA and paired t-tests (significance at p < 0.05).Results There were no significant changes in thermal, mechanical, or electrical thresholds after saline. Thermal thresholds increased at 15-60 minutes (p < 0.01) and mechanical threshold increased at 30 and 45 minutes after meperidine (p < 0.05). Maximum thermal threshold was +4.1 +/- 0.3 degrees C above baseline at 15 minutes while maximum mechanical threshold was 296 +/- 265 mmHg above baseline at 30 minutes after meperidine. Electrical thresholds following meperidine were not significantly different than baseline (p > 0.05). Thermal and electrical thresholds after meperidine were significantly higher than saline at 30 and 45 minutes (p < 0.05), and at 120 minutes (p < 0.05), respectively. Mechanical thresholds were significantly higher than saline treatment at 30 minutes (p <= 0.05).Conclusion and clinical relevance Electrical stimulation did not detect meperidine analgesia whereas both thermal and mechanical thresholds changed after meperidine administration in cats.-
Formato: dc.format543-547-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-Blackwell-
Relação: dc.relationVeterinary Anaesthesia and Analgesia-
Relação: dc.relation2.064-
Relação: dc.relation0,800-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectanalgesia-
Palavras-chave: dc.subjectcat-
Palavras-chave: dc.subjectelectrical-
Palavras-chave: dc.subjectmechanical-
Palavras-chave: dc.subjectthermal-
Palavras-chave: dc.subjectthresholds-
Título: dc.titleEffects of meperidine or saline on thermal, mechanical and electrical nociceptive thresholds in cats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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