Chitosan/Carbomer-based tablets containing Metronidazole for potential treatment of periodontal diseases

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBalcárková, Jana-
Autor(es): dc.creatorCarvalho, Flavia Chiva-
Autor(es): dc.creatorFerrari, Priscileila Colerato-
Autor(es): dc.creatorCury, Beatriz Stringhetti Ferreira-
Autor(es): dc.creatorEvangelista, Raul Cesar-
Autor(es): dc.creatorGremião, Maria Palmira Daflon-
Autor(es): dc.creatorCastro, Ana Dóris de-
Data de aceite: dc.date.accessioned2021-03-10T22:26:28Z-
Data de disponibilização: dc.date.available2021-03-10T22:26:28Z-
Data de envio: dc.date.issued2016-01-28-
Data de envio: dc.date.issued2016-01-28-
Data de envio: dc.date.issued2012-
Fonte completa do material: dc.identifierhttp://connection.ebscohost.com/c/articles/84424616/chitosan-carbomer-based-tablets-containing-metronidazole-potential-treatment-periodontal-diseases-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/133930-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/133930-
Descrição: dc.descriptionMucoadhesive tablets with different mixtures of chitosan and carbomer homopolymer type B were prepared in order to obtain new formulations containing metronidazole for periodontal disease treatment. All tablets were characterized by swelling and erosion studies, ex vivo mucoadhesion force and in vitro drug release. The drug released mechanism was described by Korsmeyer-Peppas and Weibull models. Tablets containing increased amounts of chitosan presented higher swelling ability and the drug release was prolonged in the simulated saliva fluid. The mechanisms for the drug release from tablets were complex, including diffusion, swelling and erosion simultaneously. This kind of delivery system is suitable for formulating metronidazole mucoadhesive systems, representing a good alternative for the local treatment of periodontal diseases.-
Formato: dc.format3339-3342-
Idioma: dc.languageen-
Relação: dc.relationJournal of Pharmacy Research-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectMucoadhesive tablets-
Palavras-chave: dc.subjectPeriodontal disease-
Palavras-chave: dc.subjectMetronidazole-
Palavras-chave: dc.subjectChitosan-
Palavras-chave: dc.subjectCarbomer-
Palavras-chave: dc.subjectDrug delivery-
Título: dc.titleChitosan/Carbomer-based tablets containing Metronidazole for potential treatment of periodontal diseases-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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