A dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis

Registro completo de metadados
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPedrolli, Danielle Biscaro-
Autor(es): dc.creatorKühm, Christian-
Autor(es): dc.creatorSévin, Daniel C.-
Autor(es): dc.creatorVockenhuber, Michael P.-
Autor(es): dc.creatorSauer, Uwe-
Autor(es): dc.creatorSuess, Beatrix-
Autor(es): dc.creatorMack, Matthias-
Data de aceite: dc.date.accessioned2021-03-10T22:19:38Z-
Data de disponibilização: dc.date.available2021-03-10T22:19:38Z-
Data de envio: dc.date.issued2015-12-07-
Data de envio: dc.date.issued2015-12-07-
Data de envio: dc.date.issued2015-10-22-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1073/pnas.1515024112-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/131658-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/131658-
Descrição: dc.descriptionFlavin mononucleotide (FMN) riboswitches are genetic elements, which in many bacteria control genes responsible for biosynthesis and/or transport of riboflavin (rib genes). Cytoplasmic riboflavin is rapidly and almost completely converted to FMN by flavokinases. When cytoplasmic levels of FMN are sufficient (high levels), FMN binding to FMN riboswitches leads to a reduction of rib gene expression. We report here that the protein RibR counteracts the FMN-induced turn-off activities of both FMN riboswitches in Bacillus subtilis, allowing rib gene expression even in the presence of high levels of FMN. The reason for this secondary metabolic control by RibR is to couple sulfur metabolism with riboflavin metabolism.-
Formato: dc.format14054–14059-
Idioma: dc.languageen-
Relação: dc.relationProceedings Of The National Academy Of Sciences Of The United States Of America-
Relação: dc.relation6,092-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectBacillus subtilis-
Palavras-chave: dc.subjectFmn riboswitch-
Palavras-chave: dc.subjectRibr-
Palavras-chave: dc.subjectFlavin mononucleotide-
Palavras-chave: dc.subjectRiboflavin-
Título: dc.titleA dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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