Evaluation of Diuron (3-[3,4-dichlorophenyl]-1,1-dimethyl urea) in a Two-stage Mouse Skin Carcinogenesis Assay

Registro completo de metadados
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorFerrucio, Bianca-
Autor(es): dc.creatorda Silva Franchi, Carla Adriene-
Autor(es): dc.creatorBoldrin, Natalia Ferreira-
Autor(es): dc.creatorOliveira, Maria Luiza Cotrim Sartor de-
Autor(es): dc.creatorCamargo, João Lauro Viana de-
Data de aceite: dc.date.accessioned2021-03-10T16:58:51Z-
Data de disponibilização: dc.date.available2021-03-10T16:58:51Z-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2010-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/0192623310375452-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/13004-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/13004-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionProcesso FAPESP: 06/60506-1-
Descrição: dc.descriptionProcesso FAPESP: 06/04630-5-
Descrição: dc.descriptionProcesso FAPESP: 08/01809-0-
Descrição: dc.descriptionDiuron (3-[3,4-dichlorophenyl]-1,1-dimethyl urea) is an herbicide with carcinogenic activity in rats and mice, which have developed respectively urothelial and mammary gland tumors in long-term studies. Accordingly, diuron has been categorized as a "likely human carcinogen" by the U. S. Environmental Protection Agency. Although the carcinogenesis-initiating activity of diuron has been reported in an early initiation-promotion mouse skin study, its genotoxic potential has been disputed. It is necessary to clarify the mode of action through which it has caused rodent neoplasia and verify its relevance to humans. Herein, two experiments were developed to verify the initiating and promoting potentials of diuron in a twenty-three-and a twenty-one-week-long mouse skin carcinogenesis protocol. In one, dimethylsulfoxide (DMSO) was the solvent for the herbicide; in the other, acetone was the alternative solvent in order to verify whether DMSO had inhibitory influence on a potential cutaneous carcinogenic activity. The adopted schedule for the tumor-promoting agent 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in skin ulcers, which demonstrates the need for careful selection of TPA dose levels and frequency of application in this model. In both studies, diuron did not exert any influence on the skin carcinogenesis process, in contrast with results already reported in the literature.-
Formato: dc.format756-764-
Idioma: dc.languageen-
Publicador: dc.publisherSage Publications Inc-
Relação: dc.relationToxicologic Pathology-
Relação: dc.relation1.966-
Relação: dc.relation0,807-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectdiuron (3-[3; 4-dichlorophenyl]-; 1-dimethyl urea)-
Palavras-chave: dc.subjectskin carcinogenesis-
Palavras-chave: dc.subjectinitiation-promotion-
Palavras-chave: dc.subjectDMSO-
Palavras-chave: dc.subjectTPA-
Título: dc.titleEvaluation of Diuron (3-[3,4-dichlorophenyl]-1,1-dimethyl urea) in a Two-stage Mouse Skin Carcinogenesis Assay-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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