Lack of Chemopreventive Activity of Agaricus blazei Mushroom on the Development of 1,2-Dimethylhydrazine-Induced Colonic Aberrant Crypt Foci in Rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRibeiro-Santos, Giovanna-
Autor(es): dc.creatorBarbisan, Luis Fernando-
Autor(es): dc.creatorLopes, Fabiane Catanho-
Autor(es): dc.creatorTozzi Spinardi-Barbisan, Ana Lucia-
Autor(es): dc.creatorda Eira, Augusto Ferreira-
Autor(es): dc.creatorKaneno, Ramon-
Data de aceite: dc.date.accessioned2021-03-10T16:58:47Z-
Data de disponibilização: dc.date.available2021-03-10T16:58:47Z-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2008-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/01635580802196115-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/12981-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/12981-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionProcesso FAPESP: 98/07726-5R-
Descrição: dc.descriptionChemopreventive and immunomodulatory potential of methanolic (MET) and dichloromethanic (DCl) extracts of Agaricus blazei mushroom were investigated in the postinitiation stage of colon carcinogenesis in male Wistar rats. Animals were initiated with 1,2-dimethylhydrazine (DMH) and treated i.g. with DCl or MET extracts. After 9 wk, animals were sacrificed for evaluation of aberrant crypt foci (ACF) development, crypt cellular proliferation, preneoplastic liver lesions (GST-P), proliferative response of spleen cells to mitogen, and natural killer activity. Administration of DCl extracts did not suppress DMH-induced colonic ACF nor did it affect the crypt multiplicity, but the highest dose of MET significantly reduced the development of preneoplastic lesions in the colon and liver. Lymphoproliferative response was slightly decreased in the initiated control group, which was restored by treatment with MET. No toxicity from DCl and MET extracts was observed (groups MET and DCl).-
Formato: dc.format768-775-
Idioma: dc.languageen-
Publicador: dc.publisherLawrence Erlbaum Assoc Inc-taylor & Francis-
Relação: dc.relationNutrition and Cancer-an International Journal-
Relação: dc.relation2.261-
Relação: dc.relation0,745-
Direitos: dc.rightsclosedAccess-
Título: dc.titleLack of Chemopreventive Activity of Agaricus blazei Mushroom on the Development of 1,2-Dimethylhydrazine-Induced Colonic Aberrant Crypt Foci in Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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