Tumor microenvironmental genomic alterations in juvenile nasopharyngeal angiofibroma

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSilveira, Sara Martoreli-
Autor(es): dc.creatorDomingues, Maria Aparecida Custódio-
Autor(es): dc.creatorButugan, Ossamu-
Autor(es): dc.creatorBrentani, Maria Mitzi-
Autor(es): dc.creatorRogatto, Silvia Regina-
Data de aceite: dc.date.accessioned2021-03-10T16:58:41Z-
Data de disponibilização: dc.date.available2021-03-10T16:58:41Z-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2012-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/hed.21767-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/12945-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/12945-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionBackground To better characterize the pathophysiology of juvenile nasopharyngeal angiofibroma (JNA), endothelial and stromal cells were evaluated by genomic imbalances in association with transcript expression levels of genes mapped on these altered regions.Methods. High-resolution comparative genomic hybridization (HR-CGH) was used in laser-captured endothelial and stromal cells from 9 JNAs. Ten genes were evaluated by quantitative real-timereverse transcription polymerase chain reaction (qRT-PCR) in 15 cases.Results. Although gains were more frequently detected in endothelial cells, 57% of chromosomal alterations were common by both components. Gene expression analyses revealed a positive correlation between endothelial and stromal components for ASPM, CDH1, CTNNB1, FGF18, and SUPT16H. A significant difference was found for FGF18 and AURKB overexpression in stromal cells and AR down-expression in endothelial cells.Conclusions. A similar pattern of gene expression and chromosomal imbalances in both exponents would suggest a common mechanism of functional regulation. AURKB, FGF18, and SUPT16H were identified as potential molecular markers in JNA. (C) 2011 Wiley Periodicals, Inc. Head Neck 34: 485-492, 2012-
Formato: dc.format485-492-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-Blackwell-
Relação: dc.relationHead and Neck: Journal for the Sciences and Specialties of the Head and Neck-
Relação: dc.relation2.471-
Relação: dc.relation1,254-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectjuvenile nasopharyngeal angiofibromas-
Palavras-chave: dc.subjectquantitative real-time RT-PCR-
Palavras-chave: dc.subjectchromosomal imbalances-
Palavras-chave: dc.subjecthigh-resolution comparative genomic hybridization-
Palavras-chave: dc.subjecttumor microenvironment-
Título: dc.titleTumor microenvironmental genomic alterations in juvenile nasopharyngeal angiofibroma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.