High plasma uric acid concentration: causes and consequences

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Oliveira, Erick Prado-
Autor(es): dc.creatorBurini, Roberto Carlos-
Data de aceite: dc.date.accessioned2021-03-10T16:58:37Z-
Data de disponibilização: dc.date.available2021-03-10T16:58:37Z-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2012-04-04-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/1758-5996-4-12-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/12886-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/12886-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionHigh plasma uric acid (UA) is a precipitating factor for gout and renal calculi as well as a strong risk factor for Metabolic Syndrome and cardiovascular disease. The main causes for higher plasma UA are either lower excretion, higher synthesis or both. Higher waist circumference and the BMI are associated with higher insulin resistance and leptin production, and both reduce uric acid excretion. The synthesis of fatty acids (tryglicerides) in the liver is associated with the de novo synthesis of purine, accelerating UA production. The role played by diet on hyperuricemia has not yet been fully clarified, but high intake of fructose-rich industrialized food and high alcohol intake (particularly beer) seem to influence uricemia. It is not known whether UA would be a causal factor or an antioxidant protective response. Most authors do not consider the UA as a risk factor, but presenting antioxidant function. UA contributes to > 50% of the antioxidant capacity of the blood. There is still no consensus if UA is a protective or a risk factor, however, it seems that acute elevation is a protective factor, whereas chronic elevation a risk for disease.-
Formato: dc.format7-
Idioma: dc.languageen-
Publicador: dc.publisherBiomed Central Ltd.-
Relação: dc.relationDiabetology & Metabolic Syndrome-
Relação: dc.relation2.413-
Relação: dc.relation0,943-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectUric acid-
Palavras-chave: dc.subjectDiet-
Palavras-chave: dc.subjectProtection-
Palavras-chave: dc.subjectRisk-
Palavras-chave: dc.subjectMetabolic syndrome-
Título: dc.titleHigh plasma uric acid concentration: causes and consequences-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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