Screening test for antibiotics in medicinal plants (STAMP): using powdered plant materials instead of extracts

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorInácio, Marielle Cascaes-
Autor(es): dc.creatorCarmona, Fabio-
Autor(es): dc.creatorPaz, Tiago Antunes-
Autor(es): dc.creatorFurlan, Maysa-
Autor(es): dc.creatorSilva, Fernando Arcanjo da-
Autor(es): dc.creatorBertoni, Bianca Waléria-
Autor(es): dc.creatorFrança, Suzelei de Castro-
Autor(es): dc.creatorSoares, Ana Maria Pereira-
Data de aceite: dc.date.accessioned2021-03-10T21:51:21Z-
Data de disponibilização: dc.date.available2021-03-10T21:51:21Z-
Data de envio: dc.date.issued2015-05-15-
Data de envio: dc.date.issued2015-05-15-
Data de envio: dc.date.issued2013-
Fonte completa do material: dc.identifierhttp://www.scirp.org/journal/PaperInformation.aspx?PaperID=40622#.VU0M6_lViko-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/123581-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/123581-
Descrição: dc.descriptionCoordenação de Aprefeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionProcesso FAPESP: 2010/15168-6-
Descrição: dc.descriptionPlants are a rich source of antibiotics, but screening all the existing plant species for biological activity using current methods can be time and resource consuming. The present study is to investigate whether powdered plant materials would perform as well as plant extracts in the screening of plants with antimicrobial activity. In the new method proposed (STAMP), we compared in vitro antimicrobial activity of powdered plant materials from 12 species against bacteria and fungi. We confirmed these results with their corresponding aqueous (wet) and hydro-alcoholic extracts and one species testing the antimicrobial activity of two isolated compounds. Compared with hydro-alcoholic extracts, screening using the powdered plant materials correctly identified the majority of the species with antimicrobial activity against Candida albicans (sensitivity 91%, specificity 86%), C. parapsilosis (sensitivity 100%, specificity 67%), and Staphylococcus aureus (sensitivity 64%, specificity 86%). For bacteria, the method performed better in a pH of 9.0. The antimicrobial activity of two compounds isolated from one species (maytenin and netzahualcoyone) confirmed the results. In conclusion, the use of powdered plant materials for screening plants with antimicrobial properties is a cheap, widely available, technically easy, time sparing, reproducible, and sensitive method and can significantly shorten the time and money spent during drug development.-
Formato: dc.format2340-2350-
Idioma: dc.languagept_BR-
Relação: dc.relationAmerican Journal of Plant Sciences-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectHerbal Drug-
Palavras-chave: dc.subjectBotanical Drug-
Palavras-chave: dc.subjectPhytotherapics-
Palavras-chave: dc.subjectNatural Products-
Título: dc.titleScreening test for antibiotics in medicinal plants (STAMP): using powdered plant materials instead of extracts-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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