Cord blood cytokine levels in focal early-onset neonatal infection after preterm premature rupture of membranes

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorKurokawa, Cilmery Suemi-
Autor(es): dc.creatorHashimoto, Miriam-
Autor(es): dc.creatorRugolo, Ligia Maria Suppo de Souza-
Autor(es): dc.creatorBentlin, Maria Regina-
Autor(es): dc.creatorGolim, Márjorie de Assis-
Autor(es): dc.creatorPeraçoli, José Carlos-
Autor(es): dc.creatorSilva, Marcia Guimarães da-
Autor(es): dc.creatorCorrente, José Eduardo-
Autor(es): dc.creatorWiegerinck Fekete, Saskia Maria-
Data de aceite: dc.date.accessioned2021-03-10T21:34:51Z-
Data de disponibilização: dc.date.available2021-03-10T21:34:51Z-
Data de envio: dc.date.issued2015-03-18-
Data de envio: dc.date.issued2015-03-18-
Data de envio: dc.date.issued2013-11-01-
Fonte completa do material: dc.identifierhttp://www.turkishjournalpediatrics.org/?fullTextId=1266&lang=eng-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/117802-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/117802-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionProcesso FAPESP: 10/11507-0-
Descrição: dc.descriptionThis study aimed to evaluate the levels of pro-and anti-inflammatory cytokines in umbilical cord blood of preterm neonates who developed focal early-onset infection (EOI) after preterm premature rupture of membranes (PPROM). This is a prospective study conducted on 46 preterm infants from mothers with PPROM. The cytokines were measure by flow cytometry. Newborns were classified into two groups as focal EOI (n=19) and non-infected (n=27). Interleukin (IL)-6 and IL-8 levels were higher, whereas IL-10 and IL-12 p70 levels were lower in the EOI when compared to the non-infected group. The best combination of cytokines was IL-6+IL-8, with a diagnostic accuracy of 0.97. Focal EOI after PPROM is associated with increased levels of IL-6 and IL-8 and diminished IL-10 and IL-12 in the cord blood of preterm infants. Combined assessment of IL-6 and IL-8 in cord blood may provide an additional tool for identifying preterm infants who develop EOI after PPROM.-
Formato: dc.format598-605-
Idioma: dc.languageen-
Publicador: dc.publisherTurkish J Pediatrics-
Relação: dc.relationTurkish Journal Of Pediatrics-
Relação: dc.relation0.187-
Relação: dc.relation0,173-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectearly infection-
Palavras-chave: dc.subjectin vivo inflammation-
Palavras-chave: dc.subjectcytokine-
Palavras-chave: dc.subjectinnate immunity-
Palavras-chave: dc.subjectinfant-
Palavras-chave: dc.subjectpremature-
Título: dc.titleCord blood cytokine levels in focal early-onset neonatal infection after preterm premature rupture of membranes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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