Determination of pantoprazole in human plasma by LC-MS-MS using lansoprazole as internal standard

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPeres, O.-
Autor(es): dc.creatorOliveira, C. H.-
Autor(es): dc.creatorBarrientos-Astigarraga, R. E.-
Autor(es): dc.creatorRezende, V. M.-
Autor(es): dc.creatorMendes, G. D.-
Autor(es): dc.creatorNucci, G. de-
Data de aceite: dc.date.accessioned2021-03-10T21:31:24Z-
Data de disponibilização: dc.date.available2021-03-10T21:31:24Z-
Data de envio: dc.date.issued2015-03-18-
Data de envio: dc.date.issued2015-03-18-
Data de envio: dc.date.issued2004-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1055/s-0031-1296977-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/116876-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/116876-
Descrição: dc.descriptionAn analytical method based on liquid chromatography with positive ion electrospray ionization (ESI) coupled to tandem mass spectrometry detection was developed for the determination of pantoprazole (CAS 102625-70-7) in human plasma using lansoprazole (CAS 103577-45-3) as the internal standard. The analyte and internal standard were extracted from the plasma samples by liquid/liquid extraction using diethyl-ether/dichloromethane (70:30; v/v) and chromatographed on a C-8 analytical column. The mobile phase consisted of acetonitrile/water/methanol (57:25:18; v/v/v) + 10 mmol/l acetic acid + 20 mmol/l ammonium acetate. The method has a chromatographic total run time of 4.5 min and was linear within the range 5.0-5,000 ng/mL. Detection was performed on a triple quadrupole tandem mass spectrometer by Multiple Reaction Monitoring (MRM). The intra- and inter-run precisions calculated from quality control (QC) samples were 4.2% and 3.2%, respectively. The accuracies as determined from QC samples were -5.0% (intra-run) and 2.0% (inter-run). The method herein described was employed in a bioequivalence study of two tablet formulations of pantoprazole.-
Formato: dc.format314-319-
Idioma: dc.languageen-
Publicador: dc.publisherEcv-editio Cantor Verlag Medizin Naturwissenschaften-
Relação: dc.relationArzneimittel-forschung-drug Research-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectCAS 102625-70-7-
Palavras-chave: dc.subjectpantoprazole, determination in human plasma-
Palavras-chave: dc.subjectproton pump inhibitor-
Título: dc.titleDetermination of pantoprazole in human plasma by LC-MS-MS using lansoprazole as internal standard-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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