Natural Products from Cyanobacteria with Antimicrobial and Antitumor Activity

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSilva-Stenico, Maria Estela-
Autor(es): dc.creatorKaneno, Ramon-
Autor(es): dc.creatorZambuzi, Fabiana Albani-
Autor(es): dc.creatorVaz, Marcelo G. M. V.-
Autor(es): dc.creatorAlvarenga, Danillo O.-
Autor(es): dc.creatorFiore, Marli Fatima-
Data de aceite: dc.date.accessioned2021-03-10T21:20:04Z-
Data de disponibilização: dc.date.available2021-03-10T21:20:04Z-
Data de envio: dc.date.issued2014-12-03-
Data de envio: dc.date.issued2014-12-03-
Data de envio: dc.date.issued2013-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2174/1389201014666131227114846-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/112641-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/112641-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionBrazilian National Research Council-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionProcesso FAPESP: 09/05474-5-
Descrição: dc.descriptionProcesso FAPESP: 10/09867-9-
Descrição: dc.descriptionProcesso FAPESP: 10/18732-0-
Descrição: dc.descriptionProcesso FAPESP: 11/08092-6-
Descrição: dc.descriptionProcesso FAPESP: 11/20307-8-
Descrição: dc.descriptionCNPq: 559720/2009-2-
Descrição: dc.descriptionCNPq: 308299/2009-4-
Descrição: dc.descriptionCNPq: 303952/2010-5-
Descrição: dc.descriptionCNPq: 151931/2010-0-
Descrição: dc.descriptionCyanobacteria are an important source of structurally bioactive metabolites, with cytotoxic, antiviral, anticancer, antimitotic, antimicrobial, specific enzyme inhibition and immunosuppressive activities. This study focused on the antitumor and antimicrobial activities of intra and extracellular cyanobacterial extracts. A total of 411 cyanobacterial strains were screened for antimicrobial activity using a subset of pathogenic bacteria as target. The in vitro antitumor assays were performed with extracts of 24 strains tested against two murine cancer cell lines (colon carcinoma CT-26 and lung cancer 3LL). Intracellular extracts inhibited 49 and 35% of Gram-negative and Gram-positive pathogenic bacterial growth, respectively. Furthermore, the methanolic intracellular extract of Cylindrospermopsis raciborskii CYP011K and Nostoc sp. CENA69 showed inhibitory activity against the cancer cell lines. The extracellular extract from Fischerella sp. CENA213 and M. aeruginosa NPJB-1 exhibited inhibitory activity against 3LL lung cancer cells at 0.8 mu g ml(-1) and Oxynema sp. CENA135, Cyanobium sp. CENA154, M. aeruginosa NPJB-1 and M. aeruginosa NPLJ-4 presented inhibitory activity against CT26 colon cancer cells at 0.8 mu g ml(-1). Other extracts were able to inhibit 3LL cell-growth at higher concentrations (20 mu g ml(-1)) such as Nostoc sp. CENA67, Cyanobium sp. CENA154 and M. aeruginosa NPLJ-4, while CT26 cells were inhibited at the same concentration by Nostoc sp. CENA67 and Fischerella sp. CENA213. These extracts presented very low inhibitory activity on human peripheral blood lymphocytes. The results showed that some cyanobacterial strains are a rich source of natural products with potential for pharmacological and biotechnological applications.-
Formato: dc.format820-828-
Idioma: dc.languageen-
Publicador: dc.publisherBentham Science Publ Ltd-
Relação: dc.relationCurrent Pharmaceutical Biotechnology-
Relação: dc.relation1.819-
Relação: dc.relation0,574-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectAntiproliferative activity-
Palavras-chave: dc.subjectAntimicrobial-
Palavras-chave: dc.subjectNatural products-
Palavras-chave: dc.subjectTumor cell lines-
Título: dc.titleNatural Products from Cyanobacteria with Antimicrobial and Antitumor Activity-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.