Systemic immunotoxicity reactions induced by adjuvanted vaccines

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBatista-Duharte, Alexander-
Autor(es): dc.creatorPortuondo, Deivys-
Autor(es): dc.creatorPerez, O.-
Autor(es): dc.creatorCarlos, Iracilda Zeppone-
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Descrição: dc.descriptionUNESP-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionVaccine safety is a topic of concern for the treated individual, the family, the health care personnel, and the others involved in vaccination programs as recipients or providers. Adjuvants are necessary components to warrant the efficacy of vaccines, however the overstimulation of the immune system is also associated with adverse effects. Local reactions are the most frequent manifestation of toxicity induced by adjuvanted vaccines and, with the exception of the acute phase response (APR), much less is known about the systemic reactions that follow vaccination. Their low frequency or subclinical expression meant that this matter has been neglected. In this review, various systemic reactions associated with immune stimulation will be addressed, including: APR, hypersensitivity, induction or worsening of autoimmune diseases, modification of hepatic metabolism and vascular leak syndrome (VLS), with an emphasis on the mechanism involved. Finally, the authors analyze the current focus of discussion about vaccine safety and opportunities to improve the design of new adjuvanted vaccines in the future. (C) 2014 Elsevier B.V. All rights reserved.-
Formato: dc.format170-180-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationInternational Immunopharmacology-
Relação: dc.relation3.118-
Relação: dc.relation1,051-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectSystemic reactions-
Palavras-chave: dc.subjectAdjuvant-
Palavras-chave: dc.subjectVaccine-
Palavras-chave: dc.subjectImmunotoxicity-
Palavras-chave: dc.subjectAction mechanisms-
Título: dc.titleSystemic immunotoxicity reactions induced by adjuvanted vaccines-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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