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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Machado, Humberto S. | - |
Autor(es): dc.creator | Sá, Paula | - |
Autor(es): dc.creator | Nunes, Catarina S. | - |
Autor(es): dc.creator | Couceiro, António | - |
Autor(es): dc.creator | Silva, Álvaro Moreira da | - |
Autor(es): dc.creator | Águas, Artur | - |
Data de aceite: dc.date.accessioned | 2019-08-21T17:03:06Z | - |
Data de disponibilização: dc.date.available | 2019-08-21T17:03:06Z | - |
Data de envio: dc.date.issued | 2015-03-03 | - |
Data de envio: dc.date.issued | 2015-03-03 | - |
Data de envio: dc.date.issued | 2014-08-11 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/10400.2/3741 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/10400.2/3741 | - |
Descrição: dc.description | Study objective: The purpose of this study was to investigate if spontaneous one-lung ventilation would induce any type of inflammatory lung response when compared to spontaneous two-lung ventilation and its intensity, by quantification of inflammatory cells in lung histology at the end of the procedure. Design: In vivo prospective randomised animal study Setting: University research laboratory Subjects: New Zealand rabbits Interventions: Rabbits (n=20) were randomly assigned to 4 groups (n=5 each group). Groups 1 and 2 were submitted to one-lung ventilation, during 20 and 75 minutes respectively; groups 3 and 4 were submitted to two-lung ventilation during 20 and 75 minutes and considered controls. Ketamine/xylazine was administered for induction and maintenance of anesthesia. One-lung ventilation was achieved by administration of air into the interpleural space, and left lung collapse was visually confirmed through the centre of the diaphragm. Measurements: Lung histology preparations were observed under light microscopy for quantification of the inflammatory response (light, moderate and severe). Main results: All subjects had at least light inflammatory response. However, rabbits submitted to one-lung ventilation had a statistically significant value for the occurrence of moderate inflammation (p<0.05). The inflammatory response found included mainly eosinophils, with an average proportion of 75/25 to other polymorphonuclear cells. No differences between groups were found regarding gas exchange, heart rate and respiratory rate. Conclusions: In this spontaneous one-lung ventilation model, lung collapse was positively associated with a greater inflammatory response when compared to normal two-lung ventilation. | - |
Idioma: dc.language | en | - |
Publicador: dc.publisher | OMICS International | - |
Relação: dc.relation | http://omicsonline.org/open-access/spontaneous-onelung-ventilation-increases-the-lung-inflammatory-response-an-experimental-pilot-study-2155-6148.1000428.php?aid=30807 | - |
Direitos: dc.rights | openAccess | - |
Palavras-chave: dc.subject | Inflammatory response | - |
Palavras-chave: dc.subject | One-lung ventilation | - |
Palavras-chave: dc.subject | Atelectasis | - |
Título: dc.title | Spontaneous one-lung ventilation increases the lung inflammatory response : an experimental pilot study | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Aberto - Universidade Aberta (Portugal) |
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