When sex matters: differences in the central nervous system as imaged by OCT through the retina

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorNunes, Ana-
Autor(es): dc.creatorSerranho, Pedro-
Autor(es): dc.creatorGuimarães, Pedro-
Autor(es): dc.creatorFerreira, João-
Autor(es): dc.creatorCastelo-Branco, Miguel-
Autor(es): dc.creatorBernardes, Rui-
Data de aceite: dc.date.accessioned2025-08-22T11:52:19Z-
Data de disponibilização: dc.date.available2025-08-22T11:52:19Z-
Data de envio: dc.date.issued2024-09-05-
Data de envio: dc.date.issued2024-09-05-
Data de envio: dc.date.issued2022-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/10400.2/16526-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/10400.2/16526-
Descrição: dc.descriptionBackground: Retinal texture has gained momentum as a source of biomarkers of neurodegeneration, as it is sensitive to subtle differences in the central nervous system from texture analysis of the neuroretina. Sex differences in the retina structure, as detected by layer thickness measurements from optical coherence tomography (OCT) data, have been discussed in the literature. However, the effect of sex on retinal interocular differences in healthy adults has been overlooked and remains largely unreported. Methods: We computed mean value fundus images for the neuroretina layers as imaged by OCT of healthy individuals. Texture metrics were obtained from these images to assess whether women and men have the same retina texture characteristics in both eyes. Texture features were tested for group mean differences between the right and left eye. Results: Corrected texture differences exist only in the female group. Conclusions: This work illustrates that the differences between the right and left eyes manifest differently in females and males. This further supports the need for tight control and minute analysis in studies where interocular asymmetry may be used as a disease biomarker, and the potential of texture analysis applied to OCT imaging to spot differences in the retina.-
Descrição: dc.descriptionThis work was supported by the Portuguese Foundation for Science and Technology (FCT) under UIDP&B/04950/2020 (M.C.-B.) and Ph.D. grant 2020.05578.BD (A.N.).-
Descrição: dc.descriptioninfo:eu-repo/semantics/publishedVersion-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Relação: dc.relationExploring texture biomarkers of neurodegeneration in the retina-
Direitos: dc.rightshttp://creativecommons.org/licenses/by/4.0/-
Palavras-chave: dc.subjectTexture analysis-
Palavras-chave: dc.subjectNeuroretina-
Palavras-chave: dc.subjectCentral nervous system-
Palavras-chave: dc.subjectSex differences-
Palavras-chave: dc.subjectInterocular asymmetry-
Palavras-chave: dc.subjectOptical coherence tomography-
Título: dc.titleWhen sex matters: differences in the central nervous system as imaged by OCT through the retina-
Aparece nas coleções:Repositório Aberto - Universidade Aberta (Portugal)

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