Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Ferreira, Hugo | - |
Autor(es): dc.creator | Martins, João | - |
Autor(es): dc.creator | Nunes, Ana | - |
Autor(es): dc.creator | Moreira, Paula I. | - |
Autor(es): dc.creator | Castelo-Branco, Miguel | - |
Autor(es): dc.creator | Ambrósio, António F. | - |
Autor(es): dc.creator | Serranho, Pedro | - |
Autor(es): dc.creator | Bernardes, Rui | - |
Data de aceite: dc.date.accessioned | 2022-02-15T14:07:48Z | - |
Data de disponibilização: dc.date.available | 2022-02-15T14:07:48Z | - |
Data de envio: dc.date.issued | 2021-03-01 | - |
Data de envio: dc.date.issued | 2021-12-30 | - |
Data de envio: dc.date.issued | 2019 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/10400.2/10530 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/10400.2/10530 | - |
Descrição: dc.description | Alzheimer’s disease (AD) is a progressive neurodegenerative disorder whose diagnosis remains a notable challenge. The literature suggests that cerebral changes precede AD symptoms by over two decades, implying a significantly advanced stage of AD by the time it is usually diagnosed. In the study herein, texture analysis was applied to computed optical coherence tomography ocular fundus images to identify differences between a group of the transgenic mouse model of the Alzheimer’s disease (3×Tg-AD) and a group of wild-type mice, at the ages of one and two-months-old. A substantial difference between groups was found at both time-points across all neuroretina’s layers. Here, the inner nuclear layer stands out both in the level of statistically significant differences and on the extension of these differences which span through the imaged area. Also, the progression of AD is suggested to be spotted by texture analysis as demonstrated by the significant difference found in the inner plexiform and the outer nuclear layers from the age of one to the age of two-months-old. These findings demonstrate the potential of the use of the retina and texture analysis to the diagnosis of AD and monitor AD progression. Besides, the differences between groups found in this study suggest that the 3×Tg-AD model may be inappropriate to study early changes associated with the AD and other animal models should be tested following the same path and rationale. Moreover, these results also suggest that the human genes present in these transgenic mice may have an impact on the neurodevelopment of offspring which would justify the significant changes found at the age of one-month-old. | - |
Descrição: dc.description | This study was funded by The Portuguese Foundation for Science and Technology (FCT) throught PTDC/EMD-EMD/28039/2017, PEst-UID/NEU/04539/2019, UID/Multi/04621/2013 and UID/04950/2017, and by FEDER-COMPETE through POCI-01-0145-FEDER-028039 and POCI-01-0145-FEDER-007440. | - |
Descrição: dc.description | info:eu-repo/semantics/publishedVersion | - |
Idioma: dc.language | en | - |
Relação: dc.relation | PTDC/EMD-EMD/28039/2017 | - |
Relação: dc.relation | PEst-UID/NEU/04539/2019 | - |
Relação: dc.relation | info:eu-repo/grantAgreement/FCT/5876/147271/PT | - |
Relação: dc.relation | UID/04950/2017 | - |
Relação: dc.relation | POCI-01-0145-FEDER-028039 | - |
Relação: dc.relation | POCI-01-0145-FEDER-007440 | - |
Direitos: dc.rights | openAccess | - |
Palavras-chave: dc.subject | Optical coherence tomography | - |
Palavras-chave: dc.subject | Retina | - |
Palavras-chave: dc.subject | Biomarkers | - |
Palavras-chave: dc.subject | Texture analysis | - |
Palavras-chave: dc.subject | Alzheimer’s disease | - |
Palavras-chave: dc.subject | Mouse model | - |
Palavras-chave: dc.subject | 3×Tg-AD | - |
Palavras-chave: dc.subject | Early diagnosis | - |
Título: dc.title | Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer’s disease | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Aberto - Universidade Aberta (Portugal) |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: